Enhanced levels of asymmetric dimethylarginine in a serum of middle age patients with myelodysplastic syndrome

Myelodysplastic syndromes (MDS) are hematological malignancies of unclear etiology where oxidative stress may contribute to the pathogenesis. Methylarginines, naturally occurring inhibitors of NO synthase, can increase superoxide generation from uncoupled NO synthase. We found significant increase i...

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Bibliographic Details
Published in:Journal of hematology and oncology 2013-08, Vol.6 (1), p.58-58, Article 58
Main Authors: Štikarová, Jana, Suttnar, Jiří, Pimková, Kristýna, Chrastinová-Mášová, Leona, Čermák, Jaroslav, Dyr, Jan E
Format: Article
Language:English
Subjects:
Adult
Arginine - analogs & derivatives
Arginine - blood
Blood transfusions
Case-Control Studies
Chromatography
Female
Genetic aspects
Hematology
Humans
Letter to the Editor
Leukemia
Male
Middle Aged
Myelodysplastic syndromes
Myelodysplastic Syndromes - blood
Nitric oxide
Oncology
Oxidative stress
Oxidative Stress - physiology
Physiological aspects
Proteins
Superoxide
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Summary:Myelodysplastic syndromes (MDS) are hematological malignancies of unclear etiology where oxidative stress may contribute to the pathogenesis. Methylarginines, naturally occurring inhibitors of NO synthase, can increase superoxide generation from uncoupled NO synthase. We found significant increase in concentrations of asymmetric dimethylarginine (0.84 ± 0.32 μmol/L, p = 0.0022) and malondialdehyde (0.77 ± 0.11 μmol/L, p 
ISSN:1756-8722
1756-8722
DOI:10.1186/1756-8722-6-58