sTREM-1 as a Prognostic Marker of Postoperative Complications in Cardiac Surgery

Cell-activating receptor TREM-1 (triggering receptor expressed on myeloid cells 1) regulates congenital immune response and contributes to systemic inflammatory response syndrome (SIRS) development. It is able to multiply cytokine production while stimulated together with the main receptors of the c...

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Bibliographic Details
Published in:ISRN inflammation 2012, Vol.2012 (2012), p.1-5
Main Authors: Golovkin, A. S., Matveeva, V. G., Grigoriev, E. V., Shukevich, D. L., Bayrakova, Y. V., Barbarash, L. S.
Format: Article
Language:English
Subjects:
Clinical Study
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Summary:Cell-activating receptor TREM-1 (triggering receptor expressed on myeloid cells 1) regulates congenital immune response and contributes to systemic inflammatory response syndrome (SIRS) development. It is able to multiply cytokine production while stimulated together with the main receptors of the congenital immune system. The purpose of the paper is to study the potential use of soluble TREM-1 (sTREM-1) as a marker of intensive SIRS and a criterion for postoperative complications prediction following on-pump coronary artery bypass surgery (CABG). Results show that early postoperative sTREM-1 concentrations demonstrate their potential prognostic value regarding SIRS-associated complications.
ISSN:2090-8695
2090-8695
DOI:10.5402/2012/382862