Relation of Uric Acid to Serum Levels of High-Sensitivity C-Reactive Protein, Triglycerides, and High-Density Lipoprotein Cholesterol and to Hepatic Steatosis

• Published in: The American journal of cardiology 2012-12, Vol.110 (12), p.1787-1792
• Main Authors: Keenan, Tanya, MPH, Blaha, Michael J., MD, MPH, Nasir, Khurram, MD, MPH, Silverman, Michael G., MD, Tota-Maharaj, Rajesh, MD, Carvalho, Jose A.M., MD, Conceição, Raquel D., MD, Blumenthal, Roger S., MD, Santos, Raul D., MD, PhD
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Biomarkers - blood; C-Reactive Protein - analysis; Cardiology. Vascular system; Cardiovascular; Cholesterol; Cholesterol, HDL - blood; Diet; Fatty Liver - blood; Fatty Liver - complications; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Insulin resistance; Linear Models; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Metabolic Syndrome - blood; Metabolic Syndrome - complications; Middle Aged; Obesity; Obesity - blood; Obesity - complications; Other diseases. Semiology; Prevalence; Proteins; Risk Factors; Surveys and Questionnaires; Triglycerides - blood; Uric Acid - blood; Young Adult
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2012.08.012

Increased uric acid (UA) is strongly linked to cardiovascular disease. However, the independent role of UA is still debated because it is associated with several cardiovascular risk factors including obesity and metabolic syndrome. This study assessed the association of UA with increased high-sensitivity C-reactive protein (hs-CRP), increased ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL), sonographically detected hepatic steatosis, and their clustering in the presence and absence of obesity and metabolic syndrome. We evaluated 3,518 employed subjects without clinical cardiovascular disease from November 2008 through July 2010. Prevalence of hs-CRP ≥3 mg/L was 19%, that of TG/HDL ≥3 was 44%, and that of hepatic steatosis was 43%. In multivariable logistic regression after adjusting for traditional cardiovascular risk factors and confounders, highest versus lowest UA quartile was associated with hs-CRP ≥3 mg/L (odds ratio [OR] 1.52, 95% confidence interval [CI] 1.01 to 2.28, p = 0.04), TG/HDL ≥3 (OR 3.29, 95% CI 2.36 to 4.60, p