Comparative Plasma Exposure of Albendazole after Administration of Rapidly Disintegrating Tablets in Dogs

The main objectives of this study were (a) to evaluate the in vitro performance of the rapid disintegration tablets as a way to improve the solid dispersions and (b) to study the in vivo pharmacokinetics of the albendazole modified formulation in dogs. Rapid disintegration of tablets seems to be a k...

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Bibliographic Details
Published in:BioMed research international 2013-01, Vol.2013 (2013), p.1-7
Main Authors: Palma, Santiago D., Lanusse, Carlos E., Allemandi, Daniel, Suarez, Gonzalo, Dib, Alicia, Castro, Silvina G., Sanchez Bruni, Sergio
Format: Article
Language:English
Subjects:
Administration, Oral
Albendazole - administration & dosage
Albendazole - blood
Albendazole - pharmacokinetics
Animals
Biological Availability
Chemistry, Pharmaceutical
Dogs
Female
Hardness
Tablets
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Summary:The main objectives of this study were (a) to evaluate the in vitro performance of the rapid disintegration tablets as a way to improve the solid dispersions and (b) to study the in vivo pharmacokinetics of the albendazole modified formulation in dogs. Rapid disintegration of tablets seems to be a key factor for efficiency of solid dispersions with regard to improvement of the albendazole bioavailability. The in vivo assays performed on dogs showed a marked increase in drug plasma exposure when albendazole was given in solid dispersions incorporated into rapid disintegration tablets compared with conventional solid dosage form.
ISSN:2314-6133
2314-6141
DOI:10.1155/2013/920305