Functional connection between posterior superior temporal gyrus and ventrolateral prefrontal cortex in human

The connection between auditory fields of the temporal lobe and prefrontal cortex has been well characterized in nonhuman primates. Little is known of temporofrontal connectivity in humans, however, due largely to the fact that invasive experimental approaches used so successfully to trace anatomica...

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Bibliographic Details
Published in:Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2013-10, Vol.23 (10), p.2309-2321
Main Authors: Garell, P C, Bakken, H, Greenlee, J D W, Volkov, I, Reale, R A, Oya, H, Kawasaki, H, Howard, M A, Brugge, J F
Format: Article
Language:English
Subjects:
Adult
Auditory Cortex - physiology
Electric Stimulation
Evoked Potentials, Auditory
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neural Pathways
Prefrontal Cortex - physiology
Primates
Young Adult
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Summary:The connection between auditory fields of the temporal lobe and prefrontal cortex has been well characterized in nonhuman primates. Little is known of temporofrontal connectivity in humans, however, due largely to the fact that invasive experimental approaches used so successfully to trace anatomical pathways in laboratory animals cannot be used in humans. Instead, we used a functional tract-tracing method in 12 neurosurgical patients with multicontact electrode arrays chronically implanted over the left (n = 7) or right (n = 5) perisylvian temporal auditory cortex (area PLST) and the ventrolateral prefrontal cortex (VLPFC) of the inferior frontal gyrus (IFG) for diagnosis and treatment of medically intractable epilepsy. Area PLST was identified by the distribution of average auditory-evoked potentials obtained in response to simple and complex sounds. The same sounds evoked little if there is any activity in VLPFC. A single bipolar electrical pulse (0.2 ms, charge-balanced) applied between contacts within physiologically identified PLST resulted in polyphasic evoked potentials clustered in VLPFC, with greatest activation being in pars triangularis of the IFG. The average peak latency of the earliest negative deflection of the evoked potential on VLPFC was 13.48 ms (range: 9.0-18.5 ms), providing evidence for a rapidly conducting pathway between area PLST and VLPFC.
ISSN:1047-3211
1460-2199
DOI:10.1093/cercor/bhs220