Amphotericin B Serum Concentrations During Therapy 1

Therapeutic outcome of patients being treated for systemic mycoses with amphotericin B is possibly related to the serum concentrations of this drug that are produced in these patients. Because current data are conflicting, the magnitude of these concentrations was restudied by using a bioassay which...

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Bibliographic Details
Published in:Applied microbiology 1970-06, Vol.19 (6), p.955-959
Main Authors: Fields, Branch T., Bates, Joseph H., Abernathy, Robert S.
Format: Article
Language:English
Subjects:
Clinical Microbiology, Virology, and Immunology
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Summary:Therapeutic outcome of patients being treated for systemic mycoses with amphotericin B is possibly related to the serum concentrations of this drug that are produced in these patients. Because current data are conflicting, the magnitude of these concentrations was restudied by using a bioassay which gave precise and accurate results. The highest of 155 serum concentrations was 2.01 μg/ml. Mean concentrations were 1.21, 0.62, and 0.32 μg/ml, at 1, 18, and 42 hr, respectively, after intravenous infusion of amphotericin B. This drug was detected in serum 7 weeks after completion of treatment, but it could not be detected 13 weeks after treatment. Drug levels did not appreciably decrease in serum stored for 8 to 9 months at − 10 C. Unequal serum content in assay tubes and measurement of assay turbidity by visual inspection may explain previously reported amphotericin B levels of 3.0 to 12.5 μg/ml.
ISSN:0003-6919
DOI:10.1128/AEM.19.6.955-959.1970