Injectable, Cellular-Scale Optoelectronics with Applications for Wireless Optogenetics

Successful integration of advanced semiconductor devices with biological systems will accelerate basic scientific discoveries and their translation into clinical technologies. In neuroscience generally, and in optogenetics in particular, the ability to insert light sources, detectors, sensors, and o...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2013-04, Vol.340 (6129), p.211-216
Main Authors: Kim, Tae-il, McCall, Jordan G., Jung, Yei Hwan, Huang, Xian, Siuda, Edward R., Li, Yuhang, Song, Jizhou, Song, Young Min, Pao, Hsuan An, Kim, Rak-Hwan, Lu, Chaofeng, Lee, Sung Dan, Song, Il-Sun, Shin, Gunchul, Al-Hasani, Ream, Kim, Stanley, Tan, Meng Peun, Huang, Yonggang, Omenetto, Fiorenzo G., Rogers, John A., Bruchas, Michael R.
Format: Article
Language:English
Subjects:
Actuators
Aerospace engineering
Animal behavior
Animals
Behavior, Animal
Biological
Brain
Brain - physiology
Brain Mapping - instrumentation
Brain Mapping - methods
Computer engineering
Electric Stimulation
Electrophysiological Phenomena
ENGINEERING
Fiber optic cables
HEK293 Cells
Humans
Light emitting diodes
Materials science
Mechanical engineering
Mice
Microelectrodes
Miniaturization
Municipal engineering
Neurons
Neurons - physiology
Neurosciences
Optical engineering
Optics
Optoelectronics
Optogenetics
Photic Stimulation
Semiconductor devices
Semiconductors
Sensors
Silicon devices
Wireless networks
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Summary:Successful integration of advanced semiconductor devices with biological systems will accelerate basic scientific discoveries and their translation into clinical technologies. In neuroscience generally, and in optogenetics in particular, the ability to insert light sources, detectors, sensors, and other components into precise locations of the deep brain yields versatile and important capabilities. Here, we introduce an injectable class of cellular-scale optoelectronics that offers such features, with examples of unmatched operational modes in optogenetics, including completely wireless and programmed complex behavioral control over freely moving animals. The ability of these ultrathin, mechanically compliant, biocompatible devices to afford minimally invasive operation in the soft tissues of the mammalian brain foreshadow applications in other organ systems, with potential for broad utility in biomédical science and engineering.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1232437