A Comparison between 18F-FDG PET/CT Imaging and Biological and Radiological Findings in Restaging of Hepatoblastoma Patients

Background. In this study we retrospectively evaluated if 18F-FDG-PET/CT provided incremental diagnostic information over CI in a group of hepatoblastoma patients performing restaging. Procedure. Nine patients (mean age: 5.9 years; range: 3.1–12 years) surgically treated for hepatoblastoma were foll...

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Bibliographic Details
Published in:BioMed research international 2013-01, Vol.2013 (2013), p.1-6
Main Authors: Quartuccio, Natale, Ficola, Umberto, Basso, Maria Eleonora, Bova, Valentina, Fania, Piercarlo, Pagano, Manuela, Treglia, Giorgio, Cistaro, Angelina, Fagioli, Franca
Format: Article
Language:English
Subjects:
Child
Child, Preschool
Fluorodeoxyglucose F18
Hepatoblastoma - diagnostic imaging
Hepatoblastoma - pathology
Humans
Liver Neoplasms - diagnostic imaging
Liver Neoplasms - pathology
Magnetic Resonance Imaging
Multimodal Imaging
Neoplasm Staging
Positron-Emission Tomography
Tomography, X-Ray Computed
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Summary:Background. In this study we retrospectively evaluated if 18F-FDG-PET/CT provided incremental diagnostic information over CI in a group of hepatoblastoma patients performing restaging. Procedure. Nine patients (mean age: 5.9 years; range: 3.1–12 years) surgically treated for hepatoblastoma were followed up by clinical examination, serum α-FP monitoring, and US. CI (CT or MRI) and PET/CT were performed in case of suspicion of relapse. Fine-needle aspiration biopsies (FNAB) were carried out for final confirmation if the results of CI, PET/CT, and/or α-FP levels were suggestive of relapse. PET/CT and CI findings were analyzed for comparison purposes, using FNAB as reference standard. Results. α-FP level was suggestive of disease recurrence in 8/9 patients. Biopsy was performed in 8/9 cases. CI and PET/CT resulted to be concordant in 5/9 patients (CI identified recurrence of disease, but 18F-FDG-PET/CT provided a better definition of disease extent); in 4/9 cases, CI diagnostic information resulted in negative findings, whereas PET/CT correctly detected recurrence of disease. 18F-FDG-PET/CT showed an agreement of 100% (8/8) with FNAB results. Conclusions. 18F-FDG-PET/CT scan seems to better assess HB patients with respect to CI and may provide incremental diagnostic value in the restaging of this group of patients.
ISSN:2314-6133
2314-6141
DOI:10.1155/2013/709037