Association between obesity and vulnerability and serologic response to influenza vaccination in older adults

Highlights ► Obesity was not associated with seroprotection to influenza vaccine in adults. ► Vulnerability was not associated with seroprotection against the 2008–2009 vaccine. ► We did observe increased seroconversion to the H3N2 subtype among obese subjects. ► Seroconversion to the H1N1 subtype w...

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Bibliographic Details
Published in:Vaccine 2012-06, Vol.30 (26), p.3937-3943
Main Authors: Talbot, H.K, Coleman, L.A, Crimin, K, Zhu, Y, Rock, M.T, Meece, J, Shay, D.K, Belongia, E.A, Griffin, M.R
Format: Article
Language:English
Subjects:
Age
Aged
Aged, 80 and over
Allergy and Immunology
Antibodies, Viral - blood
antigens
Body Mass Index
comorbidity
elderly
Female
Florida
Frailty
gender
HAI
Humans
Immune system
influenza
Influenza vaccine
Influenza Vaccines - administration & dosage
Influenza Vaccines - immunology
Influenza, Human - prevention & control
Male
Middle Aged
Obesity
Obesity - immunology
Older people
regression analysis
seroconversion
surveys
Surveys and Questionnaires
vaccination
Vaccination - methods
Vaccines
Vulnerability
Vulnerable Populations
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Description
Summary:Highlights ► Obesity was not associated with seroprotection to influenza vaccine in adults. ► Vulnerability was not associated with seroprotection against the 2008–2009 vaccine. ► We did observe increased seroconversion to the H3N2 subtype among obese subjects. ► Seroconversion to the H1N1 subtype was increased among more vulnerable subjects.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.03.071