The interactive effects of cerebral perfusion and depression on cognitive function in older adults with heart failure

Depression is common among persons with heart failure (HF) and has been linked to cognitive impairment in this population. The mechanisms of this relationship are unclear, and the current study examined whether cerebral perfusion moderates the association between depressive symptoms and cognitive im...

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Bibliographic Details
Published in:Psychosomatic medicine 2013-09, Vol.75 (7), p.632-639
Main Authors: Alosco, Michael L, Spitznagel, Mary Beth, Raz, Naftali, Cohen, Ronald, Sweet, Lawrence H, Garcia, Sarah, Josephson, Richard, van Dulmen, Manfred, Hughes, Joel, Rosneck, Jim, Gunstad, John
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Attention - physiology
Blood flow
Blood Flow Velocity
Cardiography, Impedance
Cerebrovascular Circulation - physiology
Cognition & reasoning
Cognition - physiology
Cognition Disorders - epidemiology
Cognition Disorders - physiopathology
Cognition Disorders - psychology
Depression
Depression - epidemiology
Depression - physiopathology
Depression - psychology
Executive function
Executive Function - physiology
Female
Heart failure
Heart Failure - epidemiology
Heart Failure - physiopathology
Heart Failure - psychology
Humans
Language
Linear Models
Male
Memory
Memory - physiology
Mental depression
Middle Aged
Motor Skills - physiology
Neuropsychological Tests
Neuropsychology
Older people
Psychiatric Status Rating Scales
Regression analysis
Severity of Illness Index
Task performance
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Summary:Depression is common among persons with heart failure (HF) and has been linked to cognitive impairment in this population. The mechanisms of this relationship are unclear, and the current study examined whether cerebral perfusion moderates the association between depressive symptoms and cognitive impairment in patients with HF. Persons with HF (n = 89; mean [standard deviation] age = 67.61 [11.78] years) completed neuropsychological testing and impedance cardiography. Depressive symptoms were assessed using the Beck Depression Inventory II, and transcranial Doppler was used to quantify cerebral perfusion. Depression was associated with reduced performance on tasks assessing attention/executive function (r = -0.28), language (r = -0.0.30), and motor function (r = -0.28) in unadjusted models (p values
ISSN:0033-3174
1534-7796
DOI:10.1097/PSY.0b013e31829f91da