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The interactive effects of cerebral perfusion and depression on cognitive function in older adults with heart failure

Depression is common among persons with heart failure (HF) and has been linked to cognitive impairment in this population. The mechanisms of this relationship are unclear, and the current study examined whether cerebral perfusion moderates the association between depressive symptoms and cognitive im...

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Bibliographic Details
Published in:Psychosomatic medicine 2013-09, Vol.75 (7), p.632-639
Main Authors: Alosco, Michael L, Spitznagel, Mary Beth, Raz, Naftali, Cohen, Ronald, Sweet, Lawrence H, Garcia, Sarah, Josephson, Richard, van Dulmen, Manfred, Hughes, Joel, Rosneck, Jim, Gunstad, John
Format: Article
Language:English
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Summary:Depression is common among persons with heart failure (HF) and has been linked to cognitive impairment in this population. The mechanisms of this relationship are unclear, and the current study examined whether cerebral perfusion moderates the association between depressive symptoms and cognitive impairment in patients with HF. Persons with HF (n = 89; mean [standard deviation] age = 67.61 [11.78] years) completed neuropsychological testing and impedance cardiography. Depressive symptoms were assessed using the Beck Depression Inventory II, and transcranial Doppler was used to quantify cerebral perfusion. Depression was associated with reduced performance on tasks assessing attention/executive function (r = -0.28), language (r = -0.0.30), and motor function (r = -0.28) in unadjusted models (p values
ISSN:0033-3174
1534-7796
DOI:10.1097/PSY.0b013e31829f91da