Increased Risk of Atopic Dermatitis in Preschool Children with Kawasaki Disease : A Population-Based Study in Taiwan

Kawasaki disease (KD) is an acute febrile systemic vasculitis and has been reported to be associated with allergic disease. The risk of atopic dermatitis (AD) in preschool children with KD has not been investigated. The study was to determine the longitudinal risk of the development of AD in prescho...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2013-01, Vol.2013 (2013), p.1-7
Main Authors: Woon, Peng Yeong, Chang, Wei Chiao, Liang, Chi-Cheng, Hsu, Chun Hung, Klahan, Sukhontip, Huang, Ying-Hsien, Chang, Wei-Pin, Kuo, Ho-Chang
Format: Article
Language:English
Subjects:
Age
Asthma
Atopic dermatitis
Children
Chronic obstructive pulmonary disease
Coronary vessels
Cytokines
Datasets
Dermatitis
Eczema
Food allergies
Health insurance
Health risks
Immunoglobulin E
Immunology
Industrialized nations
Interleukin 5
Kawasaki disease
Mucocutaneous lymph node syndrome
Population
Population studies
Population-based studies
Preschool children
Risk factors
Statistical models
Systemic vasculitis
Veins & arteries
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Summary:Kawasaki disease (KD) is an acute febrile systemic vasculitis and has been reported to be associated with allergic disease. The risk of atopic dermatitis (AD) in preschool children with KD has not been investigated. The study was to determine the longitudinal risk of the development of AD in preschool children with KD. A nationwide 5-year population-based study was performed using data from the National Health Insurance Database in Taiwan between 1999 and 2003. The risk factors for AD were compared between the 2 study groups during the follow-up period using the Cox proportional hazards model. In addition, plasma interleukin (IL)-5 levels were analyzed in normal subjects and KD patients. Among the 1440 subjects included, 21.6% developed AD during the 5-year follow-up period, of which 30.3% and 18.7% belonged to the study cohort and the comparison group, respectively. Children with KD were 1.25 times more likely to have AD than those in controls (P=0.04). Levels of IL-5 and IgE were significantly higher in KD patients. Children with KD had a higher risk of developing AD during the 5-year follow-up period than the control group. Increased IL-5 and IgE levels may be key factors contributing to the risk of AD.
ISSN:1741-427X
1741-4288
DOI:10.1155/2013/605123