Dangguijakyak-San Protects against 1-Methyl-4-phenyl-1,2,3,6,-tetrahydropyridine-Induced Neuronal Damage via Anti-Inflammatory Action

Dangguijakyak-san (DJS), a famous traditional Korean multiherbal medicine, has been used to treat gynecological and neuro-associated disease. Recent studies demonstrated that DJS has multiple bioactivities including neuroprotection. In the present study, we were to investigate the effect of DJS and...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2013-01, Vol.2013 (2013), p.1-8
Main Authors: Hwang, Deok-Sang, Kim, Hyo Geun, Jang, Jun-Bock, Oh, Myung Sook
Format: Article
Language:English
Subjects:
Animal cognition
Antigens
Apoptosis
Cell culture
Dopamine
Dopamine receptors
Gangrene
Gliosis
Herbal medicine
Inflammation
Locomotor activity
Microglial cells
Motor activity
Movement disorders
MPTP
Neurodegeneration
Neurodegenerative diseases
Neuroprotection
Neurosciences
Neurotoxicity
Nitric oxide
Oxidative stress
Parkinson's disease
Rodents
Substantia nigra
Toxicity
Tumor necrosis factor
Tumor necrosis factor-TNF
Tumor necrosis factor-α
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Summary:Dangguijakyak-san (DJS), a famous traditional Korean multiherbal medicine, has been used to treat gynecological and neuro-associated disease. Recent studies demonstrated that DJS has multiple bioactivities including neuroprotection. In the present study, we were to investigate the effect of DJS and its mechanism in an in vitro and in vivo model of Parkinson’s disease (PD). In primary mesencephalic culture system, DJS attenuated the dopaminergic cell damage induced by 1-methyl-4-phenylpyridine toxicity, and it inhibited production of inflammatory factors such as tumor necrosis factor α (TNF-α), nitric oxide (NO), and activation of microglial cells. Then, we confirmed the effect of DJS in a mouse PD model induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). In the pole test, DJS at 50 mg/kg/day for 5 days showed increase of motor activity showing shortened time to turn and locomotor activity compared with the MPTP only treated mice. In addition, DJS significantly protected nigrostriatal dopaminergic neuron from MPTP stress. Moreover, DJS showed inhibition of gliosis in the substantia nigra pars compacta. These results have therapeutic implications for DJS in the treatment of PD via anti-inflammatory effects.
ISSN:1741-427X
1741-4288
DOI:10.1155/2013/976270