The Invisible Arm of Immunity in Common Cancer Chemoprevention Agents

Immunoprevention refers to a strategy of preventing pathogen-associated and spontaneous cancers through the use of vaccines, antibodies, and immune modulators. Immune modulators function by enhancing the endogenous ability of the immune system to monitor for malignancy, so-called "immunosurveil...

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Bibliographic Details
Published in:Cancer prevention research (Philadelphia, Pa.) Pa.), 2013-08, Vol.6 (8), p.764-773
Main Authors: MARZBANI, Edmond, INATSUKA, Carol, HAILING LU, DISIS, Mary L
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Antineoplastic Agents - therapeutic use
Biological and medical sciences
Humans
Immunity, Cellular - drug effects
Medical sciences
Miscellaneous
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Neoplasms - immunology
Neoplasms - prevention & control
Prevention and actions
Public health. Hygiene
Public health. Hygiene-occupational medicine
Tumors
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Summary:Immunoprevention refers to a strategy of preventing pathogen-associated and spontaneous cancers through the use of vaccines, antibodies, and immune modulators. Immune modulators function by enhancing the endogenous ability of the immune system to monitor for malignancy, so-called "immunosurveillance." There is growing evidence that many of the most promising cancer chemoprevention agents including aspirin, COX-2 inhibitors, aromatase inhibitors, and bisphosphonates mediate their effects, in part, by enhancing immunosurveillance and reversing the immune evasive mechanisms that premalignant lesions use. In the following review, we introduce critical components of the human immune surveillance system-dendritic cells, T cells, and immune suppressive cells-and discuss the emerging data suggesting that common chemoprevention agents may modulate the function of these immunologic cells.
ISSN:1940-6207
1940-6215
1940-6215
DOI:10.1158/1940-6207.capr-13-0036