Redox-Neutral Copper(II) Carboxylate Catalyzed α-Alkynylation of Amines

Cocktail of three: A new strategy for iminium ion isomerization was applied to the direct, redox‐neutral α‐alkynylation of amines. Copper(II) 2‐ethylhexanoate [Cu(2‐EH)2] was identified as the optimal catalyst for this three‐component coupling reaction of secondary amines, aldehydes, and alkynes. MW...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2013-03, Vol.52 (13), p.3765-3769
Main Authors: Das, Deepankar, Sun, Aaron X., Seidel, Daniel
Format: Article
Language:English
Subjects:
Amines - chemistry
azomethine ylides
Carboxylic Acids - chemistry
Catalysis
copper
Copper - chemistry
CH activation
heterocycles
Isomerism
microwave chemistry
Microwaves
Oxidation-Reduction
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Summary:Cocktail of three: A new strategy for iminium ion isomerization was applied to the direct, redox‐neutral α‐alkynylation of amines. Copper(II) 2‐ethylhexanoate [Cu(2‐EH)2] was identified as the optimal catalyst for this three‐component coupling reaction of secondary amines, aldehydes, and alkynes. MW=microwave.
ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.201300021