Food for thought: The role of appetitive peptides in age-related cognitive decline

Highlights ► Beyond metabolic activities, appetitive peptides facilitate hippocampal plasticity. ► Insulin and leptin promote plasticity directly and through the orexin system. ► Orexin projections through the basal forebrain modulate hippocampal neurochemistry. ► Deficits in these peptide systems c...

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Bibliographic Details
Published in:Ageing research reviews 2013-06, Vol.12 (3), p.764-776
Main Authors: Fadel, Jim R, Jolivalt, Corinne G, Reagan, Lawrence P
Format: Article
Language:English
Subjects:
Aging - physiology
Alzheimer Disease - metabolism
Alzheimer Disease - physiopathology
Animals
Appetite Regulation - physiology
Hippocampus - physiology
Humans
Insulin - physiology
Internal Medicine
Intracellular Signaling Peptides and Proteins - physiology
Leptin - physiology
Neurology
Neuronal Plasticity - physiology
Neuropeptides - physiology
Orexins
Peptides - physiology
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Summary:Highlights ► Beyond metabolic activities, appetitive peptides facilitate hippocampal plasticity. ► Insulin and leptin promote plasticity directly and through the orexin system. ► Orexin projections through the basal forebrain modulate hippocampal neurochemistry. ► Deficits in these peptide systems contribute to age-related cognitive decline. ► Appetitive peptides represent novel targets in the treatment of dementia and AD.
ISSN:1568-1637
1872-9649
DOI:10.1016/j.arr.2013.01.009