Plasma Levels of Soluble Receptor for Advanced Glycation End Products and Coronary Atherosclerosis: Possible Correlation with Clinical Presentation

Receptor for Advanced Glycation End-products (RAGE) is a multi-ligand receptor ubiquitous present on epithelial, neuronal, vascular and inflammatory cells, usually expressed at low levels in homeostasis and to increased degrees at sites of stress or injury. The aim of the present study was to evalua...

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Bibliographic Details
Published in:Disease markers 2013-01, Vol.2013 (2013), p.1-6
Main Authors: Pelissero, Gabriele, Falcone, Rossana, Benzi, Alberto, Colonna, Anna, Matrone, Benedetta, D'Angelo, Angela, Bozzini, Sara, Falcone, Colomba, Paganini, Edoardo Maria
Format: Article
Language:English
Subjects:
Acute Coronary Syndrome - blood
Acute Coronary Syndrome - diagnosis
Aged
Biomarkers - blood
Clinical Study
Coronary Artery Disease - blood
Coronary Artery Disease - diagnosis
Female
Humans
Male
Middle Aged
Receptor for Advanced Glycation End Products - blood
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Summary:Receptor for Advanced Glycation End-products (RAGE) is a multi-ligand receptor ubiquitous present on epithelial, neuronal, vascular and inflammatory cells, usually expressed at low levels in homeostasis and to increased degrees at sites of stress or injury. The aim of the present study was to evaluate sRAGE plasma levels in patients with Acute Coronary Syndrome (ACS) and to assess its diagnostic efficacy in identification of patients with acute events. Plasma levels of sRAGE were determined in 860 patients with Coronary Artery Disease (CAD): 530 patients presented stable angina and 330 were observed during acute ischemic event (147 with unstable angina and 183 with myocardial infarction). sRAGE plasma levels were significantly lower in patients with ACS than in patients with stable angina: [median 584 pg/mL (IQR: 266–851 pg/mL) in MI patients, median 769 pg/mL (IQR: 394–987 pg/mL) in patients with unstable angina, median 834 pg/mL (IQR 630–1005 pg/mL) in patients with stable angina; P
ISSN:0278-0240
1875-8630
DOI:10.1155/2013/129360