Quantitative analysis of generation and branch defects in G5 poly(amidoamine) dendrimer

Although methods have been developed to synthesize and isolate generation 5 (G5) PAMAM dendrimers containing precise numbers of ligands per polymer particle, the presence of skeletal and generational defects in this material can substantially hamper the process. Here we provide a quantitative analys...

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Bibliographic Details
Published in:Polymer (Guilford) 2013-07, Vol.54 (16), p.4126-4133
Main Authors: van Dongen, Mallory A., Desai, Ankur, Orr, Bradford G., Baker, James R., Banaszak Holl, Mark M.
Format: Article
Language:English
Subjects:
Applied sciences
Exact sciences and technology
high performance liquid chromatography
HPLC
Mass spectrometry
nuclear magnetic resonance spectroscopy
Organic polymers
PAMAM dendrimer
Physicochemistry of polymers
polymers
Properties and characterization
quantitative analysis
size exclusion chromatography
Structure, morphology and analysis
titration
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Summary:Although methods have been developed to synthesize and isolate generation 5 (G5) PAMAM dendrimers containing precise numbers of ligands per polymer particle, the presence of skeletal and generational defects in this material can substantially hamper the process. Here we provide a quantitative analysis of G5 PAMAM dendrimer defects via high performance liquid chromatography, potentiometric titration, mass spectrometry, size exclusion chromatography, and nuclear magnetic resonance. We identified, isolated, and characterized the major structural defects of G5 dendrimer, trailing generations, and dimer, trimer, and tetramer species. We determine that the G5 material present in the as-received mixture contains 93 arms on average. We have developed two model systems capable of generating the experimentally observed mass range and polydispersity at defect rates of 8–15%. [Display omitted]
ISSN:0032-3861
1873-2291
DOI:10.1016/j.polymer.2013.05.062