Adiabatic inversion pulses for myocardial T1 mapping

• Published in: Magnetic resonance in medicine 2014-04, Vol.71 (4), p.1428-1434
• Main Authors: Kellman, Peter, Herzka, Daniel A., Hansen, Michael Schacht
• Format: Article
• Language: English
• Subjects: adiabatic inversion; Algorithms; Heart - anatomy & histology; Humans; Image Enhancement - methods; Image Interpretation, Computer-Assisted - methods; Magnetic Resonance Imaging - methods; MOLLI; MRI; Phantoms, Imaging; Reproducibility of Results; Sensitivity and Specificity; T1 mapping
• ISSN: 0740-3194; 1522-2594
• DOI: 10.1002/mrm.24793

Purpose To evaluate the error in T1 estimates using inversion‐recovery‐based T1 mapping due to imperfect inversion and to perform a systematic study of adiabatic inversion pulse designs in order to maximize inversion efficiency for values of transverse relaxation (T2) in the myocardium subject to a peak power constraint. Methods The inversion factor for hyperbolic secant and tangent/hyperbolic tangent adiabatic full passage waveforms was calculated using Bloch equations. A brute‐force search was conducted for design parameters: pulse duration, frequency range, shape parameters, and peak amplitude. A design was selected that maximized the inversion factor over a specified range of amplitude and off‐resonance and validated using phantom measurements. Empirical correction for imperfect inversion was performed. Results The tangent/hyperbolic tangent adiabatic pulse was found to outperform hyperbolic secant designs and achieve an inversion factor of 0.96 within ±150 Hz over 25% amplitude range with 14.7 µT peak amplitude. T1 mapping errors of the selected design due to imperfect inversion was ∼4% and could be corrected to