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Co-administration of a commonly used Zimbabwean herbal treatment (African potato) does not alter the pharmacokinetics of lopinavir/ritonavir
Summary Objective African potato ( Hypoxis obtusa) is commonly used in Sub-Saharan Africa as a complementary herbal remedy for HIV-infected patients. It is unknown whether or not co-administration of African potato alters the pharmacokinetics of protease inhibitor antiretrovirals. The objective of t...
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Published in: | International journal of infectious diseases 2013-10, Vol.17 (10), p.e857-e861 |
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description | Summary Objective African potato ( Hypoxis obtusa) is commonly used in Sub-Saharan Africa as a complementary herbal remedy for HIV-infected patients. It is unknown whether or not co-administration of African potato alters the pharmacokinetics of protease inhibitor antiretrovirals. The objective of this study was to investigate the impact of the African potato on the steady-state pharmacokinetics of ritonavir-boosted lopinavir (LPV/r). Methods Sixteen adult volunteers were administered LPV/r 400/100 mg twice a day for 14 days, followed by concomitant administration with African potato given once daily for 7 days. Lopinavir plasma exposure as estimated by the area under the concentration–time curve over the 12-h dosing interval (AUC0–12h , AUCτ) was determined on day 14 and again on day 21. Lopinavir in plasma was analyzed using a validated liquid chromatography with tandem mass spectrometry (LC-MS/MS) method. Steady-state AUCτ and the maximum concentration following dose administration (Cmax ) were determined using non-compartmental methods using WinNonlin Professional version 5.2.1. Statistical analyses were performed using Stata version 12.1. Results Co-administration of African potato was not associated with any change in lopinavir AUCτ, Cmax , or Ctrough. Conclusions African potato when taken concomitantly with LPV/r is well-tolerated and not associated with clinically significant changes in lopinavir pharmacokinetics. |
doi_str_mv | 10.1016/j.ijid.2013.02.017 |
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Joseph</creator><creatorcontrib>Gwaza, Luther ; Aweeka, Francesca ; Greenblatt, Ruth ; Lizak, Patricia ; Huang, Liusheng ; Guglielmo, B. Joseph</creatorcontrib><description>Summary Objective African potato ( Hypoxis obtusa) is commonly used in Sub-Saharan Africa as a complementary herbal remedy for HIV-infected patients. It is unknown whether or not co-administration of African potato alters the pharmacokinetics of protease inhibitor antiretrovirals. The objective of this study was to investigate the impact of the African potato on the steady-state pharmacokinetics of ritonavir-boosted lopinavir (LPV/r). Methods Sixteen adult volunteers were administered LPV/r 400/100 mg twice a day for 14 days, followed by concomitant administration with African potato given once daily for 7 days. Lopinavir plasma exposure as estimated by the area under the concentration–time curve over the 12-h dosing interval (AUC0–12h , AUCτ) was determined on day 14 and again on day 21. Lopinavir in plasma was analyzed using a validated liquid chromatography with tandem mass spectrometry (LC-MS/MS) method. Steady-state AUCτ and the maximum concentration following dose administration (Cmax ) were determined using non-compartmental methods using WinNonlin Professional version 5.2.1. Statistical analyses were performed using Stata version 12.1. Results Co-administration of African potato was not associated with any change in lopinavir AUCτ, Cmax , or Ctrough. Conclusions African potato when taken concomitantly with LPV/r is well-tolerated and not associated with clinically significant changes in lopinavir pharmacokinetics.</description><identifier>ISSN: 1201-9712</identifier><identifier>EISSN: 1878-3511</identifier><identifier>DOI: 10.1016/j.ijid.2013.02.017</identifier><identifier>PMID: 23587599</identifier><language>eng</language><publisher>Canada: Elsevier Ltd</publisher><subject><![CDATA[Adult ; Alkynes - administration & dosage ; Alkynes - pharmacology ; Anti-HIV Agents - administration & dosage ; Anti-HIV Agents - pharmacokinetics ; Area Under Curve ; Cross-Over Studies ; Drug Therapy, Combination ; Female ; Glucosides - administration & dosage ; Glucosides - pharmacology ; Herbal medicines ; Herb–drug interactions ; HIV Infections - drug therapy ; Humans ; Hypoxis obtusa ; Infectious Disease ; Lopinavir - administration & dosage ; Lopinavir - pharmacokinetics ; Male ; Middle Aged ; Pharmacokinetic interactions ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; Pulmonary/Respiratory ; Ritonavir - administration & dosage ; Ritonavir - pharmacokinetics ; Solanum tuberosum - chemistry ; Young Adult]]></subject><ispartof>International journal of infectious diseases, 2013-10, Vol.17 (10), p.e857-e861</ispartof><rights>International Society for Infectious Diseases</rights><rights>2013 International Society for Infectious Diseases</rights><rights>Copyright © 2013 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.</rights><rights>2013 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-faf19efa5eaf0b559bac21c636438495f776bb86e4d09369dff508670b72edbf3</citedby><cites>FETCH-LOGICAL-c510t-faf19efa5eaf0b559bac21c636438495f776bb86e4d09369dff508670b72edbf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1201971213001082$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,3536,27901,27902,45756</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23587599$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gwaza, Luther</creatorcontrib><creatorcontrib>Aweeka, Francesca</creatorcontrib><creatorcontrib>Greenblatt, Ruth</creatorcontrib><creatorcontrib>Lizak, Patricia</creatorcontrib><creatorcontrib>Huang, Liusheng</creatorcontrib><creatorcontrib>Guglielmo, B. Joseph</creatorcontrib><title>Co-administration of a commonly used Zimbabwean herbal treatment (African potato) does not alter the pharmacokinetics of lopinavir/ritonavir</title><title>International journal of infectious diseases</title><addtitle>Int J Infect Dis</addtitle><description>Summary Objective African potato ( Hypoxis obtusa) is commonly used in Sub-Saharan Africa as a complementary herbal remedy for HIV-infected patients. It is unknown whether or not co-administration of African potato alters the pharmacokinetics of protease inhibitor antiretrovirals. The objective of this study was to investigate the impact of the African potato on the steady-state pharmacokinetics of ritonavir-boosted lopinavir (LPV/r). Methods Sixteen adult volunteers were administered LPV/r 400/100 mg twice a day for 14 days, followed by concomitant administration with African potato given once daily for 7 days. Lopinavir plasma exposure as estimated by the area under the concentration–time curve over the 12-h dosing interval (AUC0–12h , AUCτ) was determined on day 14 and again on day 21. Lopinavir in plasma was analyzed using a validated liquid chromatography with tandem mass spectrometry (LC-MS/MS) method. Steady-state AUCτ and the maximum concentration following dose administration (Cmax ) were determined using non-compartmental methods using WinNonlin Professional version 5.2.1. Statistical analyses were performed using Stata version 12.1. Results Co-administration of African potato was not associated with any change in lopinavir AUCτ, Cmax , or Ctrough. Conclusions African potato when taken concomitantly with LPV/r is well-tolerated and not associated with clinically significant changes in lopinavir pharmacokinetics.</description><subject>Adult</subject><subject>Alkynes - administration & dosage</subject><subject>Alkynes - pharmacology</subject><subject>Anti-HIV Agents - administration & dosage</subject><subject>Anti-HIV Agents - pharmacokinetics</subject><subject>Area Under Curve</subject><subject>Cross-Over Studies</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Glucosides - administration & dosage</subject><subject>Glucosides - pharmacology</subject><subject>Herbal medicines</subject><subject>Herb–drug interactions</subject><subject>HIV Infections - drug therapy</subject><subject>Humans</subject><subject>Hypoxis obtusa</subject><subject>Infectious Disease</subject><subject>Lopinavir - administration & dosage</subject><subject>Lopinavir - pharmacokinetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pharmacokinetic interactions</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacology</subject><subject>Pulmonary/Respiratory</subject><subject>Ritonavir - administration & dosage</subject><subject>Ritonavir - pharmacokinetics</subject><subject>Solanum tuberosum - chemistry</subject><subject>Young Adult</subject><issn>1201-9712</issn><issn>1878-3511</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9kk2LFDEQhhtR3HX1D3iQHPXQvfmY_gJZWAa_YMGDevESKumKk97upEkys8x_8EebdnRRD55S8Nb7FpWniuI5oxWjrLkcKzvaoeKUiYryirL2QXHOurYrRc3Yw1xnqexbxs-KJzGOlNJN03SPizMu6q6t-_68-L71JQyzdTamAMl6R7whQLSfZ--mI9lHHMhXOytQdwiO7DAomEgKCGlGl8jLaxOszsriEyT_igweI3E-EZgSBpJ2SJYdhBm0v7UOk9VxnTH5xTo42HAZbPI_q6fFIwNTxGe_3oviy9s3n7fvy5uP7z5sr29KXTOaSgOG9WigRjBU1XWvQHOmG9FsRLfpa9O2jVJdg5uB9qLpB2Nq2jUtVS3HQRlxUVydcpe9mnHQeY0Ak1yCnSEcpQcr_1ac3clv_iBFTqaU5wB-CtDBxxjQ3HsZlSsbOcqVjVzZSMplZpNNL_6cem_5DSM3vD41YN79YDHIqC06jYMNqJMcvP1__tU_dj1lrhqmWzxiHP0-uPyrksmYDfLTeh3rcTBBKaMdFz8AUPu6Vg</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Gwaza, Luther</creator><creator>Aweeka, Francesca</creator><creator>Greenblatt, Ruth</creator><creator>Lizak, Patricia</creator><creator>Huang, Liusheng</creator><creator>Guglielmo, B. Joseph</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20131001</creationdate><title>Co-administration of a commonly used Zimbabwean herbal treatment (African potato) does not alter the pharmacokinetics of lopinavir/ritonavir</title><author>Gwaza, Luther ; Aweeka, Francesca ; Greenblatt, Ruth ; Lizak, Patricia ; Huang, Liusheng ; Guglielmo, B. Joseph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-faf19efa5eaf0b559bac21c636438495f776bb86e4d09369dff508670b72edbf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Alkynes - administration & dosage</topic><topic>Alkynes - pharmacology</topic><topic>Anti-HIV Agents - administration & dosage</topic><topic>Anti-HIV Agents - pharmacokinetics</topic><topic>Area Under Curve</topic><topic>Cross-Over Studies</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Glucosides - administration & dosage</topic><topic>Glucosides - pharmacology</topic><topic>Herbal medicines</topic><topic>Herb–drug interactions</topic><topic>HIV Infections - drug therapy</topic><topic>Humans</topic><topic>Hypoxis obtusa</topic><topic>Infectious Disease</topic><topic>Lopinavir - administration & dosage</topic><topic>Lopinavir - pharmacokinetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pharmacokinetic interactions</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - pharmacology</topic><topic>Pulmonary/Respiratory</topic><topic>Ritonavir - administration & dosage</topic><topic>Ritonavir - pharmacokinetics</topic><topic>Solanum tuberosum - chemistry</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gwaza, Luther</creatorcontrib><creatorcontrib>Aweeka, Francesca</creatorcontrib><creatorcontrib>Greenblatt, Ruth</creatorcontrib><creatorcontrib>Lizak, Patricia</creatorcontrib><creatorcontrib>Huang, Liusheng</creatorcontrib><creatorcontrib>Guglielmo, B. Joseph</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gwaza, Luther</au><au>Aweeka, Francesca</au><au>Greenblatt, Ruth</au><au>Lizak, Patricia</au><au>Huang, Liusheng</au><au>Guglielmo, B. Joseph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Co-administration of a commonly used Zimbabwean herbal treatment (African potato) does not alter the pharmacokinetics of lopinavir/ritonavir</atitle><jtitle>International journal of infectious diseases</jtitle><addtitle>Int J Infect Dis</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>17</volume><issue>10</issue><spage>e857</spage><epage>e861</epage><pages>e857-e861</pages><issn>1201-9712</issn><eissn>1878-3511</eissn><abstract>Summary Objective African potato ( Hypoxis obtusa) is commonly used in Sub-Saharan Africa as a complementary herbal remedy for HIV-infected patients. It is unknown whether or not co-administration of African potato alters the pharmacokinetics of protease inhibitor antiretrovirals. The objective of this study was to investigate the impact of the African potato on the steady-state pharmacokinetics of ritonavir-boosted lopinavir (LPV/r). Methods Sixteen adult volunteers were administered LPV/r 400/100 mg twice a day for 14 days, followed by concomitant administration with African potato given once daily for 7 days. Lopinavir plasma exposure as estimated by the area under the concentration–time curve over the 12-h dosing interval (AUC0–12h , AUCτ) was determined on day 14 and again on day 21. Lopinavir in plasma was analyzed using a validated liquid chromatography with tandem mass spectrometry (LC-MS/MS) method. Steady-state AUCτ and the maximum concentration following dose administration (Cmax ) were determined using non-compartmental methods using WinNonlin Professional version 5.2.1. Statistical analyses were performed using Stata version 12.1. Results Co-administration of African potato was not associated with any change in lopinavir AUCτ, Cmax , or Ctrough. Conclusions African potato when taken concomitantly with LPV/r is well-tolerated and not associated with clinically significant changes in lopinavir pharmacokinetics.</abstract><cop>Canada</cop><pub>Elsevier Ltd</pub><pmid>23587599</pmid><doi>10.1016/j.ijid.2013.02.017</doi><oa>free_for_read</oa></addata></record> |
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subjects | Adult Alkynes - administration & dosage Alkynes - pharmacology Anti-HIV Agents - administration & dosage Anti-HIV Agents - pharmacokinetics Area Under Curve Cross-Over Studies Drug Therapy, Combination Female Glucosides - administration & dosage Glucosides - pharmacology Herbal medicines Herb–drug interactions HIV Infections - drug therapy Humans Hypoxis obtusa Infectious Disease Lopinavir - administration & dosage Lopinavir - pharmacokinetics Male Middle Aged Pharmacokinetic interactions Plant Extracts - administration & dosage Plant Extracts - pharmacology Pulmonary/Respiratory Ritonavir - administration & dosage Ritonavir - pharmacokinetics Solanum tuberosum - chemistry Young Adult |
title | Co-administration of a commonly used Zimbabwean herbal treatment (African potato) does not alter the pharmacokinetics of lopinavir/ritonavir |
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