RNA in the Loop

Long noncoding RNAs (lncRNAs) have been implicated in a variety of biological roles, particularly as cis or trans gene expression regulators. Reporting recently in Nature, Lai et al. (2013) show that a class of gene-activating lncRNAs combines two gene regulation paradigms: enhancer-directed chromos...

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Bibliographic Details
Published in:Developmental cell 2013-03, Vol.24 (6), p.565-567
Main Authors: Kung, Johnny T.Y., Lee, Jeannie T.
Format: Article
Language:English
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Summary:Long noncoding RNAs (lncRNAs) have been implicated in a variety of biological roles, particularly as cis or trans gene expression regulators. Reporting recently in Nature, Lai et al. (2013) show that a class of gene-activating lncRNAs combines two gene regulation paradigms: enhancer-directed chromosomal looping and RNA-mediated protein effector recruitment.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2013.03.009