Cell Therapy for Lung Diseases: Report from an NIH―NHLBI Workshop, November 13―14, 2012

The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health convened the Cell Therapy for Lung Disease Working Group on November 13-14, 2012, to review and formulate recommendations for future research directions. The workshop brought together investigators studying ba...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2013-08, Vol.188 (3), p.370-375
Main Authors: MATTHAY, Michael A, ANVERSA, Piero, ORTIZ, Luis A, OTT, Harald C, TENTE, William, THEBAUD, Bernard, TRAPNELL, Bruce C, WEISS, Daniel J, YUAN, Jason X.-J, BLAISDELL, Carol J, BHATTACHARYA, Jahar, BURNETT, Bruce K, CHAPMAN, Harold A, HARE, Joshua M, HEI, Derek J, HOFFMAN, Andrew M, KOUREMBANAS, Stella, MCKENNA, David H
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Applied cell therapy and gene therapy
Biological and medical sciences
Biomedical Research - methods
Bone marrow
Cell- and Tissue-Based Therapy - methods
Clinical trials
Humans
Hyperoxia
Intensive care medicine
Lung diseases
Lung Diseases - therapy
Medical sciences
National Heart, Lung, and Blood Institute (U.S.)
NHLBI Workshop
Pneumology
Stem cells
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
United States
Workshops
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Summary:The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health convened the Cell Therapy for Lung Disease Working Group on November 13-14, 2012, to review and formulate recommendations for future research directions. The workshop brought together investigators studying basic mechanisms and the roles of cell therapy in preclinical models of lung injury and pulmonary vascular disease, with clinical trial experts in cell therapy for cardiovascular diseases and experts from the NHLBI Production Assistance for Cell Therapy program. The purpose of the workshop was to discuss the current status of basic investigations in lung cell therapy, to identify some of the scientific gaps in current knowledge regarding the potential roles and mechanisms of cell therapy in the treatment of lung diseases, and to develop recommendations to the NHLBI and the research community on scientific priorities and practical steps that would lead to first-in-human trials of lung cell therapy.
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.201303-0522WS