Antiretroviral Therapy Initiated Within 6 Months of HIV Infection Is Associated With Lower T-Cell Activation and Smaller HIV Reservoir Size

Background. CD4⁺/CD8⁺ T-cell activation levels often remain elevated in chronic human immunodeficiency virus (HIV) infection despite initiation of antiretroviral therapy (ART). T-cell activation predicts early death and blunted CD4⁺ T-cell recovery during ART and may affect persistent HIV reservoir...

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Bibliographic Details
Published in:The Journal of infectious diseases 2013-10, Vol.208 (8), p.1202-1211
Main Authors: Jain, Vivek, Hartogensis, Wendy, Bacchetti, Peter, Hunt, Peter W., Hatano, Hiroyu, Sinclair, Elizabeth, Epling, Lorrie, Lee, Tzong-Hae, Busch, Michael P., McCune, Joseph M., Pilcher, Christopher D., Hecht, Frederick M., Deeks, Steven G.
Format: Article
Language:English
Subjects:
Adult
Anti-Retroviral Agents - administration & dosage
Antiretrovirals
Art therapy
Arts
Biological and medical sciences
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Cohort Studies
Disease Reservoirs - virology
DNA
DNA, Viral - blood
Female
Fundamental and applied biological sciences. Psychology
HIV
HIV infections
HIV Infections - drug therapy
HIV Infections - immunology
HIV Infections - virology
HIV-1 - growth & development
HIV-1 - immunology
HIV-1 - isolation & purification
HIV/AIDS
Human immunodeficiency virus
Human viral diseases
Humans
Infections
Infectious diseases
Lymphocyte Activation - immunology
Major and Brief Reports
Male
Medical sciences
Microbiology
Miscellaneous
RNA
RNA, Viral - blood
T lymphocytes
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral Load
Viremia
Virology
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Summary:Background. CD4⁺/CD8⁺ T-cell activation levels often remain elevated in chronic human immunodeficiency virus (HIV) infection despite initiation of antiretroviral therapy (ART). T-cell activation predicts early death and blunted CD4⁺ T-cell recovery during ART and may affect persistent HIV reservoir size. We investigated whether very early ART initiation is associated with lower on-therapy immune activation and HIV persistence. Methods. From a cohort of patients with early HIV infection (
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jit311