Ixeris dentata NAKAI Reduces Clinical Score and HIF-1 Expression in Experimental Colitis in Mice

Ixeris dentata (ID) is an herbal medicine used in Asian countries to treat indigestion, pneumonia, hepatitis, contusions, and tumors; however, its effect on intestinal inflammation is unknown. Thus, we investigated the effect of ID in the dextran sulfate sodium (DSS) model of colitis in female BALB/...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2013-01, Vol.2013 (2013), p.1-9
Main Authors: Jeon, Yong-Deok, Ko, Jang-Ho, Kim, Dae-Seung, Han, Yo-Han, Kim, Hyun-Ju, Poudel, Amrit, Jung, Hyun-Ju, Ku, Sae-Kwang, Kim, Su-Jin, Park, Sang-Hyun, Park, Jin-Han, Choi, Byung-Min, Park, Sung-Joo, Um, Jae-Young, Hong, Seung-Heon
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Body weight
Body weight loss
Cancer therapies
Colon
Cyclooxygenase-2
Cytokines
Dextran
Dextran sulfate
Diarrhea
Disease
Enzymes
Gene expression
Hepatitis
Herbal medicine
Hypoxia
Hypoxia-inducible factor 1
Hypoxia-inducible factors
Immunoglobulins
Inflammation
Inflammatory bowel disease
Inflammatory bowel diseases
Intestine
Ixeris
Mast cells
Metastases
Mice
Mucosa
Rodents
Sodium
Tumors
Ulcerative colitis
Weight loss
Weight reduction
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Summary:Ixeris dentata (ID) is an herbal medicine used in Asian countries to treat indigestion, pneumonia, hepatitis, contusions, and tumors; however, its effect on intestinal inflammation is unknown. Thus, we investigated the effect of ID in the dextran sulfate sodium (DSS) model of colitis in female BALB/c mice; animals were evaluated after seven days of DSS treatment. DSS-treated mice showed considerable clinical signs, including weight loss, reduced colon length, colonic epithelial injury, infiltration of inflammatory cells in the colon tissue, and upregulation of inflammatory mediators. However, administration of ID attenuated body weight loss, colon shortening, and the increase in disease activity index score. ID also significantly decreased the colonic mucosal injury and the number of infiltrating mast cells. Moreover, ID inhibited the expressions of cyclooxygenase-2 and hypoxia-inducible factor-1α in colon tissue. Taken together, the results provide experimental evidence that ID might be a useful therapy for patients with ulcerative colitis.
ISSN:1741-427X
1741-4288
DOI:10.1155/2013/671281