Beyond symmetry-breaking: competition and negative feedback in GTPase regulation

Highlights • Positive feedback enables the formation of cortical domains enriched in GTPases. • Competition between polarity GTPase domains assures a single winner. • In other cases, coexisting domains indicate an absence of competition. • Oscillation of GTPase levels within domains suggests the pre...

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Bibliographic Details
Published in:Trends in cell biology 2013-10, Vol.23 (10), p.476-483
Main Authors: Wu, Chi-Fang, Lew, Daniel J
Format: Article
Language:English
Subjects:
Actins - genetics
Actins - metabolism
Cdc42
cdc42 GTP-Binding Protein - genetics
cdc42 GTP-Binding Protein - metabolism
Cell Polarity - genetics
Cell Polarity - physiology
Feedback, Physiological
GAP
GEF
GTP Phosphohydrolases - genetics
GTP Phosphohydrolases - metabolism
GTPase-Activating Proteins - genetics
GTPase-Activating Proteins - metabolism
Guanine Nucleotide Exchange Factors - genetics
Guanine Nucleotide Exchange Factors - metabolism
Pathology
Plant Cells - metabolism
Plant Cells - physiology
Rac
Rop
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
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Summary:Highlights • Positive feedback enables the formation of cortical domains enriched in GTPases. • Competition between polarity GTPase domains assures a single winner. • In other cases, coexisting domains indicate an absence of competition. • Oscillation of GTPase levels within domains suggests the presence of negative feedback. • Negative feedback could confer robustness and influence competition.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2013.05.003