Study of Hormone Receptors and Epidermal Growth Factor Expression in Invasive Breast Cancers in a Cohort of Western India

• Published in: Indian journal of clinical biochemistry 2013-10, Vol.28 (4), p.403-409
• Main Authors: Dodiya, Hardik, Patel, Amit, Patel, Dipal, Kaushal, Ashish, Vijay, D. G.
• Format: Article
• Language: English
• Subjects: Analysis; Biochemistry; Biomedical and Life Sciences; Breast cancer; Cancer; Chemistry/Food Science; Cytogenetics; Epidermal growth factor; Estrogen; Estrogens; Gene expression; Immunohistochemistry; Life Sciences; Microbiology; Oncology, Experimental; Original; Original Article; Pathology; Progesterone
• ISSN: 0970-1915; 0974-0422
• DOI: 10.1007/s12291-012-0294-8

The objective of study was to evaluate and correlate the pathological characteristics of breast cancer patients with estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (Her2/neu) detected by immunohistochemistry and/or fluorescent in situ hybridization method. We have conducted 2 year study of 204 cases of breast cancer at HCG-Medisurge Hospitals, Ahmedabad from 2009 to 2011. Significant correlation was found in ER and PR expression whereas no correlation was found in hormonal receptors and Her2/neu expression. ER and PR positivity increased with advancing age in breast carcinoma patients while not affecting Her2/neu expression. The expression of hormone receptors were higher in infiltrating lobular carcinoma and infiltrating duct carcinoma subtypes of breast carcinoma as compared to other subtypes such medullary and in situ carcinoma. High-grade carcinoma patients were predominantly ER/PR negative and Her2/neu positive as compared to lower grade breast carcinoma whereas high-stage carcinoma patients were ER/PR positive and Her2/neu positive as compared to lower stage breast carcinoma.