Neuroblastoma and MYCN

Neuroblastoma, the most common extracranial solid tumor of childhood, is thought to originate from undifferentiated neural crest cells. Amplification of the MYC family member, MYCN, is found in ∼25% of cases and correlates with high-risk disease and poor prognosis. Currently, amplification of MYCN r...

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Bibliographic Details
Published in:Cold Spring Harbor perspectives in medicine 2013-10, Vol.3 (10), p.a014415-a014415
Main Authors: Huang, Miller, Weiss, William A
Format: Article
Language:English
Subjects:
Antigens, Neoplasm - genetics
Antigens, Neoplasm - immunology
Apoptosis - genetics
Cell Cycle - genetics
Cell Proliferation
Gene Amplification - genetics
Gene Expression
Genes, myc - genetics
Genetic Markers - genetics
Humans
Mutation - genetics
N-Myc Proto-Oncogene Protein
Neoplasm Metastasis
Neovascularization, Pathologic - genetics
Neuroblastoma - genetics
Neuroblastoma - pathology
Nuclear Proteins - genetics
Oncogene Proteins - genetics
Protein Stability
Risk Factors
Transcription, Genetic - genetics
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Summary:Neuroblastoma, the most common extracranial solid tumor of childhood, is thought to originate from undifferentiated neural crest cells. Amplification of the MYC family member, MYCN, is found in ∼25% of cases and correlates with high-risk disease and poor prognosis. Currently, amplification of MYCN remains the best-characterized genetic marker of risk in neuroblastoma. This article reviews roles for MYCN in neuroblastoma and highlights recent identification of other driver mutations. Strategies to target MYCN at the level of protein stability and transcription are also reviewed.
ISSN:2157-1422
2472-5412
DOI:10.1101/cshperspect.a014415