Antileukotriene Reverts the Early Effects of Inflammatory Response of Distal Parenchyma in Experimental Chronic Allergic Inflammation

Aims. Compare the effects of montelukast or dexamethasone in distal lung parenchyma and airway walls of guinea pigs (GP) with chronic allergic inflammation. Methods. GP have inhaled ovalbumin (OVA group-2x/week/4weeks). After the 4th inhalation, GP were treated with montelukast or dexamethasone. Aft...

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Bibliographic Details
Published in:BioMed research international 2013-01, Vol.2013 (2013), p.1-15
Main Authors: Leick, Edna Aparecida, Martins, Milton Arruda, Prado, Carla M., Lopes, Fernanda Degobbi Tenório Quirino dos Santos, Fumagalli, Stella Bruna Napolitano, de Souza, Flávia Castro Ribas, Gobbato, Nathália Brandão, Tibério, Iolanda F. L. C.
Format: Article
Language:English
Subjects:
Acetates - administration & dosage
Administration, Inhalation
Animal models
Animals
Chronic Disease - drug therapy
Dexamethasone - administration & dosage
Disease Models, Animal
Guinea Pigs
Hypersensitivity - drug therapy
Hypersensitivity - pathology
Inflammation - chemically induced
Inflammation - drug therapy
Inflammation - pathology
Leukotriene Antagonists - administration & dosage
Lung - drug effects
Lung - pathology
Ovalbumin - toxicity
Quinolines - administration & dosage
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Summary:Aims. Compare the effects of montelukast or dexamethasone in distal lung parenchyma and airway walls of guinea pigs (GP) with chronic allergic inflammation. Methods. GP have inhaled ovalbumin (OVA group-2x/week/4weeks). After the 4th inhalation, GP were treated with montelukast or dexamethasone. After 72 hours of the 7th inhalation, GP were anesthetised, and lungs were removed and submitted to histopathological evaluation. Results. Montelukast and dexamethasone treatments reduced the number of eosinophils in airway wall and distal lung parenchyma compared to OVA group (P
ISSN:2314-6133
2314-6141
DOI:10.1155/2013/523761