Dynamic optical coherence tomography measurements of elastic wave propagation in tissue-mimicking phantoms and mouse cornea in vivo

We demonstrate the use of phase-stabilized swept-source optical coherence tomography to assess the propagation of low-amplitude (micron-level) waves induced by a focused air-pulse system in tissue-mimicking phantoms, a contact lens, a silicone eye model, and the mouse cornea in vivo. The results sho...

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Bibliographic Details
Published in:Journal of biomedical optics 2013-12, Vol.18 (12), p.121503-121503
Main Authors: Li, Jiasong, Wang, Shang, Manapuram, Ravi Kiran, Singh, Manmohan, Menodiado, Floredes M, Aglyamov, Salavat, Emelianov, Stanislav, Twa, Michael D, Larin, Kirill V
Format: Article
Language:English
Subjects:
Animals
Biocompatibility
Biomechanical Phenomena - physiology
Biomedical materials
Cornea
Cornea - physiology
Dynamics
Elastic Modulus - physiology
Elasticity Imaging Techniques - instrumentation
Elasticity Imaging Techniques - methods
In vivo testing
In vivo tests
Mice
Phantoms, Imaging
Special Section Papers
Surgical implants
Tomography, Optical Coherence - instrumentation
Tomography, Optical Coherence - methods
Wave propagation
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Summary:We demonstrate the use of phase-stabilized swept-source optical coherence tomography to assess the propagation of low-amplitude (micron-level) waves induced by a focused air-pulse system in tissue-mimicking phantoms, a contact lens, a silicone eye model, and the mouse cornea in vivo. The results show that the wave velocity can be quantified from the analysis of wave propagation, thereby enabling the estimation of the sample elasticity using the model of surface wave propagation for the tissue-mimicking phantoms. This noninvasive, noncontact measurement technique involves low-force methods of tissue excitation that can be potentially used to assess the biomechanical properties of ocular and other delicate tissues in vivo.
ISSN:1083-3668
1560-2281
DOI:10.1117/1.JBO.18.12.121503