Resveratrol Protects the Brain of Obese Mice from Oxidative Damage

Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a polyphenolic phytoalexin that exerts cardioprotective, neuroprotective, and antioxidant effects. Recently it has been shown that obesity is associated with an increase in cerebral oxidative stress levels, which may enhance neurodegeneration. The pr...

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Published in:Oxidative medicine and cellular longevity 2013-01, Vol.2013 (2013), p.1-7
Main Authors: Rege, Shraddha D., Kumar, Sruthi, Wilson, David N., Tamura, Leslie, Geetha, Thangiah, Mathews, Suresh T., Huggins, Kevin W., Broderick, Tom L., Babu, Jeganathan Ramesh
Format: Article
Language:English
Subjects:
Animals
Antioxidants - metabolism
Blood Glucose - drug effects
Blood Glucose - metabolism
Body Weight - drug effects
Brain - drug effects
Brain - enzymology
Brain - pathology
Hydrogen Peroxide - metabolism
Lipid Peroxidation - drug effects
Male
Malondialdehyde - metabolism
Mice
Mice, Obese
Neuroprotective Agents - pharmacology
Obesity - drug therapy
Obesity - enzymology
Obesity - metabolism
Obesity - pathology
Oxidative Stress - drug effects
Stilbenes - pharmacology
Thinness - blood
Thinness - pathology
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Summary:Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a polyphenolic phytoalexin that exerts cardioprotective, neuroprotective, and antioxidant effects. Recently it has been shown that obesity is associated with an increase in cerebral oxidative stress levels, which may enhance neurodegeneration. The present study evaluates the neuroprotective action of resveratrol in brain of obese (ob/ob) mice. Resveratrol was administered orally at the dose of 25 mg kg−1 body weight daily for three weeks to lean and obese mice. Resveratrol had no effect on body weight or blood glucose levels in obese mice. Lipid peroxides were significantly increased in brain of obese mice. The enzymatic antioxidants superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase and nonenzymatic antioxidants tocopherol, ascorbic acid, and glutathione were decreased in obese mice brain. Administration of resveratrol decreased lipid peroxide levels and upregulated the antioxidant activities in obese mice brain. Our findings indicate a neuroprotective effect of resveratrol by preventing oxidative damage in brain tissue of obese mice.
ISSN:1942-0900
1942-0994
DOI:10.1155/2013/419092