Different thermodynamic signatures for DNA minor groove binding with changes in salt concentration and temperature

The effects of salt concentration and temperature on the thermodynamics of DNA minor groove binding have quite different signatures: binding enthalpy is salt concentration independent but temperature dependent. Conversely, binding free energy is salt dependent but essentially temperature independent...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2013-10, Vol.49 (76), p.8543-8545
Main Authors: Wang, Shuo, Kumar, Arvind, Aston, Karl, Nguyen, Binh, Bashkin, James K, Boykin, David W, Wilson, W David
Format: Article
Language:English
Subjects:
Binding Sites
Chemical communication
DNA - chemistry
Molecular Structure
Salts - chemistry
Sodium Chloride - chemistry
Thermodynamics
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Summary:The effects of salt concentration and temperature on the thermodynamics of DNA minor groove binding have quite different signatures: binding enthalpy is salt concentration independent but temperature dependent. Conversely, binding free energy is salt dependent but essentially temperature independent through enthalpy-entropy compensation.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc44569k