Illuminating the Petite Picture of T Cell Memory Responses to Listeria monocytogenes

The ease to culture, moderately less safety constraints in handling, and above all, hurdle free induction of an anticipated infection in mouse rendered Listeria monocytogenes the rank of a model organism for studying a variety of host immune responses. Listeria monocytogenes being an intracellular p...

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Bibliographic Details
Published in:BioMed research international 2013-01, Vol.2013 (2013), p.1-10
Main Authors: Zubair, Swaleha, Owais, Mohammad, Badrealam, Khan Farheen, Tufail, Saba
Format: Article
Language:English
Subjects:
Animals
B-Lymphocytes - immunology
Bacterial Vaccines - immunology
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Health aspects
Humans
Immunologic memory
Immunologic Memory - immunology
Immunology
Infections
Listeria monocytogenes
Listeria monocytogenes - immunology
Microbiology
Physiological aspects
Review
T cell receptors
T cells
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Summary:The ease to culture, moderately less safety constraints in handling, and above all, hurdle free induction of an anticipated infection in mouse rendered Listeria monocytogenes the rank of a model organism for studying a variety of host immune responses. Listeria monocytogenes being an intracellular pathogen evokes potent CD8 T cell response during which CD8 T cells pass through a massive expansion phase. This is generally followed by contraction phase wherein majority of activated cells undergo apoptosis leaving behind a population of memory CD8 T cells that has potential to confer enhanced protection upon reencounter with the same pathogen. Functional attributes of various cytokines, transcription factors, receptors, adaptors, and effectors pertaining to the generation of robust memory T cell response have begun to be unravelled for better understanding of memory and opening avenues to create superior vaccine strategies. This review is an attempt to unveil related discoveries along with updating recent advances on this issue.
ISSN:2314-6133
2314-6141
2314-6141
DOI:10.1155/2013/121684