First Evidence of Increased Plasma Serotonin Levels in Tako-Tsubo Cardiomyopathy

Background. There is no data about the serotonergic activity during the acute phase of Tako-Tsubo Cardiomyopathy (TTC). The objective of our study was to investigate evidence of serotonin release from patients with TTC in comparison with patients with ST elevation myocardial infarction (STEMI) and h...

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Bibliographic Details
Published in:BioMed research international 2013-01, Vol.2013 (2013), p.1-5
Main Authors: Galinier, Michel, Parini, A., Lairez, Olivier, Spreux-Varoquaux, O., Dumonteil, N., Boudou, N., Biendel-Picquet, C., Pizzinat, N., Mialet-Perez, J., Delmas, C., Rouzaud Laborde, C., Carrie, D.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biomedical research
Cardiomyopathy
Cardiovascular disease
Case-Control Studies
Clinical Study
Drug therapy
Female
Heart attacks
Humans
Life Sciences
Male
Middle Aged
Myocardial Infarction
Myocardial Infarction - blood
Myocardial Stunning
Myocardial Stunning - blood
Plasma
Serotonin
Serotonin - blood
Serotonin - physiology
Stress, Physiological
Stress, Psychological
Studies
Takotsubo Cardiomyopathy
Takotsubo Cardiomyopathy - blood
Takotsubo Cardiomyopathy - etiology
Takotsubo Cardiomyopathy - physiopathology
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Summary:Background. There is no data about the serotonergic activity during the acute phase of Tako-Tsubo Cardiomyopathy (TTC). The objective of our study was to investigate evidence of serotonin release from patients with TTC in comparison with patients with ST elevation myocardial infarction (STEMI) and healthy control subjects (HCS). Methods and Results. Plasma serotonin levels in 14 consecutive patients with TTC were compared with those in 14 patients with STEMI and 14 HCS. Plasma serotonin levels at admission were markedly higher in patients with TTC and STEMI as compared to HCS (3.9±4.6, P=0.02 versus control; 5.7±5.6, P=0.001 versus control; and 1±0.4 ng/mL, resp.). There was no difference in serotonin levels between patients with TTC and those with STEMI (P=0.33). Conclusion. This finding suggests that serotonin could participate to the pathophysiology of TTC.
ISSN:2314-6133
2314-6141
DOI:10.1155/2013/847069