Is JmjC Oxygenase Catalysis Limited to Demethylation?

Jobs on the side: Substrate selectivity studies indicate that members of the biomedically important JmjC demethylase family of histone Nε‐methyllysine demethylases are capable of catalyzing the de‐N‐alkylation of groups other than N‐methyl and can catalyze reactions that form stable hydroxylated pro...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2013-07, Vol.52 (30), p.7709-7713
Main Authors: Hopkinson, Richard J., Walport, Louise J., Münzel, Martin, Rose, Nathan R., Smart, Tristan J., Kawamura, Akane, Claridge, Timothy D. W., Schofield, Christopher J.
Format: Article
Language:English
Subjects:
Binding
Catalysis
Communications
demethylation
Enzymes
epigenetics
histone
Histones
Histones - genetics
Histones - metabolism
Humans
Hydroxylation
Inhibitors
Jumonji Domain-Containing Histone Demethylases - genetics
Jumonji Domain-Containing Histone Demethylases - metabolism
Magnetic Resonance Spectroscopy
Methylation
methyllysine
Selectivity
Substrate Specificity
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Summary:Jobs on the side: Substrate selectivity studies indicate that members of the biomedically important JmjC demethylase family of histone Nε‐methyllysine demethylases are capable of catalyzing the de‐N‐alkylation of groups other than N‐methyl and can catalyze reactions that form stable hydroxylated products. The differences in binding preferences in this set of enzymes may be helpful in the design of selective inhibitors.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201303282