3D static elastography at the micrometer scale using Full Field OCT

Full-Field OCT (FF-OCT) is able to image biological tissues in 3D with micrometer resolution. In this study we add elastographic contrast to the FF-OCT modality. By combining FF-OCT with elastography, we create a virtual palpation map at the micrometer scale. We present here a proof of concept on mu...

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Bibliographic Details
Published in:Biomedical optics express 2013, Vol.4 (10), p.2138-2149
Main Authors: Nahas, Amir, Bauer, Morgane, Roux, Stéphane, Boccara, A Claude
Format: Article
Language:English
Subjects:
Engineering Sciences
Human health and pathology
Life Sciences
Mechanics
Medical and biological imaging
microscopy
Optical Coherence Tomography
Three-dimensional microscopy
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Summary:Full-Field OCT (FF-OCT) is able to image biological tissues in 3D with micrometer resolution. In this study we add elastographic contrast to the FF-OCT modality. By combining FF-OCT with elastography, we create a virtual palpation map at the micrometer scale. We present here a proof of concept on multi-layer phantoms and preliminary results on ex vivo biological samples such as porcine cornea, human breast tissues and rat heart. The 3D digital volume correlation that is used in connection with the 3D stack of images allows to access to the full 3D strain tensor and to reveal stiffness anisotropy.
ISSN:2156-7085
2156-7085
DOI:10.1364/BOE.4.002138