Non-contact in vivo diffuse optical imaging using a time-gated scanning system

We report on the design and first in vivo tests of a novel non-contact scanning imaging system for time-domain near-infrared spectroscopy. Our system is based on a null source-detector separation approach and utilizes polarization-selective detection and a fast-gated single-photon avalanche diode to...

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Bibliographic Details
Published in:Biomedical optics express 2013, Vol.4 (10), p.2257-2268
Main Authors: Mazurenka, M, Di Sieno, L, Boso, G, Contini, D, Pifferi, A, Mora, A Dalla, Tosi, A, Wabnitz, H, Macdonald, R
Format: Article
Language:English
Subjects:
Diffuse Optical Imaging
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Summary:We report on the design and first in vivo tests of a novel non-contact scanning imaging system for time-domain near-infrared spectroscopy. Our system is based on a null source-detector separation approach and utilizes polarization-selective detection and a fast-gated single-photon avalanche diode to record late photons only. The in-vivo tests included the recording of hemodynamics during arm occlusion and two brain activation tasks. Localized and non-localized changes in oxy- and deoxyhemoglobin concentration were detected for motor and cognitive tasks, respectively. The tests demonstrate the feasibility of non-contact imaging of absorption changes in deeper tissues.
ISSN:2156-7085
2156-7085
DOI:10.1364/BOE.4.002257