RNA binding proteins in the regulation of heart development

In vivo, RNA molecules are constantly accompanied by RNA binding proteins (RBPs), which are intimately involved in every step of RNA biology, including transcription, editing, splicing, transport and localization, stability, and translation. RBPs therefore have opportunities to shape gene expression...

Full description

Saved in:
Bibliographic Details
Published in:The international journal of biochemistry & cell biology 2013-11, Vol.45 (11), p.2467-2478
Main Authors: Blech-Hermoni, Yotam, Ladd, Andrea N.
Format: Article
Language:English
Subjects:
Animals
Binding
Biology
cardiovascular diseases
Cardiovascular Diseases - embryology
Cardiovascular Diseases - genetics
cell biology
Cell Lineage
Development
Editing
Gene expression
Gene Expression Regulation, Developmental
Heart
Heart - embryology
Humans
Morphogenesis
Position (location)
Proteins
Regulation
Ribonucleic acids
RNA
RNA binding protein
RNA processing
RNA-binding proteins
RNA-Binding Proteins - metabolism
tissue repair
tissues
translation (genetics)
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In vivo, RNA molecules are constantly accompanied by RNA binding proteins (RBPs), which are intimately involved in every step of RNA biology, including transcription, editing, splicing, transport and localization, stability, and translation. RBPs therefore have opportunities to shape gene expression at multiple levels. This capacity is particularly important during development, when dynamic chemical and physical changes give rise to complex organs and tissues. This review discusses RBPs in the context of heart development. Since the targets and functions of most RBPs — in the heart and at large — are not fully understood, this review focuses on the expression and roles of RBPs that have been implicated in specific stages of heart development or developmental pathology. RBPs are involved in nearly every stage of cardiogenesis, including the formation, morphogenesis, and maturation of the heart. A fuller understanding of the roles and substrates of these proteins could ultimately provide attractive targets for the design of therapies for congenital heart defects, cardiovascular disease, or cardiac tissue repair.
ISSN:1357-2725
1878-5875
DOI:10.1016/j.biocel.2013.08.008