Improved immunogenicity of fusions between ethanol-treated cancer cells and dendritic cells exposed to dual TLR stimulation

Tumor-derived transforming growth factor β1 (TGFβ1) generally abrogates the immunogenicity of dendritic cells (DCs) fused to whole cancer cells. We have recently revealed that ethanol-treated neoplastic cells fused to DCs exposed to 2 Toll-like receptor agonists efficiently induce cytotoxic T lympho...

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Bibliographic Details
Published in:Oncoimmunology 2013-08, Vol.2 (8), p.e25375-e25375
Main Authors: Koido, Shigeo, Homma, Sadamu, Okamoto, Masato, Namiki, Yoshihisa, Kan, Shin, Takakura, Kazuki, Kajihara, Mikio, Uchiyama, Kan, Hara, Eiich, Ohkusa, Toshifumi, Gong, Jianlin, Tajiri, Hisao
Format: Article
Language:English
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cytotoxic T lymphocyte
DC/tumor cell fusion vaccine
dendritic cell
immunologic tumor cell death
Toll-like receptor
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Summary:Tumor-derived transforming growth factor β1 (TGFβ1) generally abrogates the immunogenicity of dendritic cells (DCs) fused to whole cancer cells. We have recently revealed that ethanol-treated neoplastic cells fused to DCs exposed to 2 Toll-like receptor agonists efficiently induce cytotoxic T lymphocytes via TGFβ1 blockade and the production of interleukin-12.
ISSN:2162-4011
2162-402X
2162-402X
DOI:10.4161/onci.25375