The PA and HA Gene-Mediated High Viral Load and Intense Innate Immune Response in the Brain Contribute to the High Pathogenicity of H5N1 Avian Influenza Virus in Mallard Ducks

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Published in:Journal of Virology 2013-10, Vol.87 (20), p.11063-11075
Main Authors: Hu, Jiao, Hu, Zenglei, Mo, Yiqun, Wu, Qiwen, Cui, Zhu, Duan, Zhiqiang, Huang, Junqing, Chen, Hongzhi, Chen, Yuxin, Gu, Min, Wang, Xiaoquan, Hu, Shunlin, Liu, Huimou, Liu, Wenbo, Liu, Xiaowen, Liu, Xiufan
Format: Article
Language:English
Subjects:
Animals
Avian influenza virus
Brain - immunology
Brain - virology
Disease Models, Animal
DNA Mutational Analysis
Ducks
Genetic Engineering
Hemagglutinin Glycoproteins, Influenza Virus - genetics
Hemagglutinin Glycoproteins, Influenza Virus - metabolism
Immunity, Innate
Influenza A Virus, H5N1 Subtype - genetics
Influenza A Virus, H5N1 Subtype - immunology
Influenza A Virus, H5N1 Subtype - isolation & purification
Influenza A Virus, H5N1 Subtype - pathogenicity
Influenza in Birds - pathology
Influenza in Birds - virology
Pathogenesis and Immunity
Reassortant Viruses - genetics
Reassortant Viruses - immunology
Reassortant Viruses - isolation & purification
Reassortant Viruses - pathogenicity
RNA Replicase - genetics
RNA Replicase - metabolism
Viral Load
Viral Proteins - genetics
Viral Proteins - metabolism
Virulence
Virulence Factors - genetics
Virulence Factors - metabolism
Virus Replication
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Summary:Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.00760-13