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The PA and HA Gene-Mediated High Viral Load and Intense Innate Immune Response in the Brain Contribute to the High Pathogenicity of H5N1 Avian Influenza Virus in Mallard Ducks
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| Published in: | Journal of Virology 2013-10, Vol.87 (20), p.11063-11075 |
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| container_end_page | 11075 |
| container_issue | 20 |
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| container_title | Journal of Virology |
| container_volume | 87 |
| creator | Hu, Jiao Hu, Zenglei Mo, Yiqun Wu, Qiwen Cui, Zhu Duan, Zhiqiang Huang, Junqing Chen, Hongzhi Chen, Yuxin Gu, Min Wang, Xiaoquan Hu, Shunlin Liu, Huimou Liu, Wenbo Liu, Xiaowen Liu, Xiufan |
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| doi_str_mv | 10.1128/JVI.00760-13 |
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</description><identifier>ISSN: 0022-538X</identifier><identifier>EISSN: 1098-5514</identifier><identifier>DOI: 10.1128/JVI.00760-13</identifier><identifier>PMID: 23926340</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>Animals ; Avian influenza virus ; Brain - immunology ; Brain - virology ; Disease Models, Animal ; DNA Mutational Analysis ; Ducks ; Genetic Engineering ; Hemagglutinin Glycoproteins, Influenza Virus - genetics ; Hemagglutinin Glycoproteins, Influenza Virus - metabolism ; Immunity, Innate ; Influenza A Virus, H5N1 Subtype - genetics ; Influenza A Virus, H5N1 Subtype - immunology ; Influenza A Virus, H5N1 Subtype - isolation & purification ; Influenza A Virus, H5N1 Subtype - pathogenicity ; Influenza in Birds - pathology ; Influenza in Birds - virology ; Pathogenesis and Immunity ; Reassortant Viruses - genetics ; Reassortant Viruses - immunology ; Reassortant Viruses - isolation & purification ; Reassortant Viruses - pathogenicity ; RNA Replicase - genetics ; RNA Replicase - metabolism ; Viral Load ; Viral Proteins - genetics ; Viral Proteins - metabolism ; Virulence ; Virulence Factors - genetics ; Virulence Factors - metabolism ; Virus Replication</subject><ispartof>Journal of Virology, 2013-10, Vol.87 (20), p.11063-11075</ispartof><rights>Copyright © 2013, American Society for Microbiology. All Rights Reserved. 2013 American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c554t-1582a7ad98898cb03ff60a4d6267e72e83e5a2ef7b6e639f6bad54b5d5477a5d3</citedby><cites>FETCH-LOGICAL-c554t-1582a7ad98898cb03ff60a4d6267e72e83e5a2ef7b6e639f6bad54b5d5477a5d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807287/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807287/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,3175,3176,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23926340$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Jiao</creatorcontrib><creatorcontrib>Hu, Zenglei</creatorcontrib><creatorcontrib>Mo, Yiqun</creatorcontrib><creatorcontrib>Wu, Qiwen</creatorcontrib><creatorcontrib>Cui, Zhu</creatorcontrib><creatorcontrib>Duan, Zhiqiang</creatorcontrib><creatorcontrib>Huang, Junqing</creatorcontrib><creatorcontrib>Chen, Hongzhi</creatorcontrib><creatorcontrib>Chen, Yuxin</creatorcontrib><creatorcontrib>Gu, Min</creatorcontrib><creatorcontrib>Wang, Xiaoquan</creatorcontrib><creatorcontrib>Hu, Shunlin</creatorcontrib><creatorcontrib>Liu, Huimou</creatorcontrib><creatorcontrib>Liu, Wenbo</creatorcontrib><creatorcontrib>Liu, Xiaowen</creatorcontrib><creatorcontrib>Liu, Xiufan</creatorcontrib><title>The PA and HA Gene-Mediated High Viral Load and Intense Innate Immune Response in the Brain Contribute to the High Pathogenicity of H5N1 Avian Influenza Virus in Mallard Ducks</title><title>Journal of Virology</title><addtitle>J Virol</addtitle><description>Article Usage Stats
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</description><subject>Animals</subject><subject>Avian influenza virus</subject><subject>Brain - immunology</subject><subject>Brain - virology</subject><subject>Disease Models, Animal</subject><subject>DNA Mutational Analysis</subject><subject>Ducks</subject><subject>Genetic Engineering</subject><subject>Hemagglutinin Glycoproteins, Influenza Virus - genetics</subject><subject>Hemagglutinin Glycoproteins, Influenza Virus - metabolism</subject><subject>Immunity, Innate</subject><subject>Influenza A Virus, H5N1 Subtype - genetics</subject><subject>Influenza A Virus, H5N1 Subtype - immunology</subject><subject>Influenza A Virus, H5N1 Subtype - isolation & purification</subject><subject>Influenza A Virus, H5N1 Subtype - pathogenicity</subject><subject>Influenza in Birds - pathology</subject><subject>Influenza in Birds - virology</subject><subject>Pathogenesis and Immunity</subject><subject>Reassortant Viruses - genetics</subject><subject>Reassortant Viruses - immunology</subject><subject>Reassortant Viruses - isolation & purification</subject><subject>Reassortant Viruses - pathogenicity</subject><subject>RNA Replicase - genetics</subject><subject>RNA Replicase - metabolism</subject><subject>Viral Load</subject><subject>Viral Proteins - genetics</subject><subject>Viral Proteins - metabolism</subject><subject>Virulence</subject><subject>Virulence Factors - genetics</subject><subject>Virulence Factors - metabolism</subject><subject>Virus Replication</subject><issn>0022-538X</issn><issn>1098-5514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqNkk1v1DAQQCMEotvCjTOyxIVDU_wRx84FaVmgu2gLFSoVN2uSTHZdEnuJk0XlT_EX8e6WCm5cPNb46Y1HM0nyjNEzxrh-9eF6cUapymnKxINkwmihUylZ9jCZUMp5KoX-epQch3BDKcuyPHucHHFR8FxkdJL8ulojuZwScDWZT8k5OkwvsLYwYEzY1Zpc2x5asvRQ76GFG9AFjNFFhiy6bnRIPmPY-F3aOjJE45se4m3m3dDbcozc4Pf5vfEShrVfobOVHW6Jb8hcfmRkurXgorZpR3Q_YVd3DDvfBbQt9DV5O1bfwpPkUQNtwKd38ST58v7d1WyeLj-dL2bTZVpJmQ0pk5qDgrrQutBVSUXT5BSyOue5QsVRC5TAsVFljrkomryEWmaljIdSIGtxkrw-eDdj2WFdYewEWrPpbQf9rfFgzb8vzq7Nym-N0FRxraLg5Z2g999HDIPpbKgwtuLQj8HEUQihqFL8P1AhdVZoxSJ6ekCr3ofQY3P_I0bNbh1MXAezXwfDRMSf_93FPfxn_hF4cQDWcTA_bI8GQmduttZoZfhOSXMhfgP6YLyB</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Hu, Jiao</creator><creator>Hu, Zenglei</creator><creator>Mo, Yiqun</creator><creator>Wu, Qiwen</creator><creator>Cui, Zhu</creator><creator>Duan, Zhiqiang</creator><creator>Huang, Junqing</creator><creator>Chen, Hongzhi</creator><creator>Chen, Yuxin</creator><creator>Gu, Min</creator><creator>Wang, Xiaoquan</creator><creator>Hu, Shunlin</creator><creator>Liu, Huimou</creator><creator>Liu, Wenbo</creator><creator>Liu, Xiaowen</creator><creator>Liu, Xiufan</creator><general>American Society for Microbiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H94</scope><scope>H95</scope><scope>L.G</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20131001</creationdate><title>The PA and HA Gene-Mediated High Viral Load and Intense Innate Immune Response in the Brain Contribute to the High Pathogenicity of H5N1 Avian Influenza Virus in Mallard Ducks</title><author>Hu, Jiao ; 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</abstract><cop>United States</cop><pub>American Society for Microbiology</pub><pmid>23926340</pmid><doi>10.1128/JVI.00760-13</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-538X |
| ispartof | Journal of Virology, 2013-10, Vol.87 (20), p.11063-11075 |
| issn | 0022-538X 1098-5514 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3807287 |
| source | PubMed (Medline); American Society for Microbiology Journals |
| subjects | Animals Avian influenza virus Brain - immunology Brain - virology Disease Models, Animal DNA Mutational Analysis Ducks Genetic Engineering Hemagglutinin Glycoproteins, Influenza Virus - genetics Hemagglutinin Glycoproteins, Influenza Virus - metabolism Immunity, Innate Influenza A Virus, H5N1 Subtype - genetics Influenza A Virus, H5N1 Subtype - immunology Influenza A Virus, H5N1 Subtype - isolation & purification Influenza A Virus, H5N1 Subtype - pathogenicity Influenza in Birds - pathology Influenza in Birds - virology Pathogenesis and Immunity Reassortant Viruses - genetics Reassortant Viruses - immunology Reassortant Viruses - isolation & purification Reassortant Viruses - pathogenicity RNA Replicase - genetics RNA Replicase - metabolism Viral Load Viral Proteins - genetics Viral Proteins - metabolism Virulence Virulence Factors - genetics Virulence Factors - metabolism Virus Replication |
| title | The PA and HA Gene-Mediated High Viral Load and Intense Innate Immune Response in the Brain Contribute to the High Pathogenicity of H5N1 Avian Influenza Virus in Mallard Ducks |
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