Glycopolymer probes of signal transduction

Glycans are key participants in biological processes ranging from reproduction to cellular communication to infection. Revealing glycan roles and the underlying molecular mechanisms by which glycans manifest their function requires access to glycan derivatives that vary systematically. To this end,...

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Bibliographic Details
Published in:Chemical Society reviews 2013-05, Vol.42 (10), p.4476-4491
Main Authors: Kiessling, Laura L, Grim, Joseph C
Format: Article
Language:English
Subjects:
Bearing
Biomimetic Materials - chemistry
Biomimetic Materials - metabolism
Carbohydrates
Cellular communication
Derivatives
Glycan
Glycopolymers
Humans
Molecular Probes - chemistry
Molecular Probes - metabolism
Mucins - chemistry
Mucins - metabolism
Polymers
Polymers - chemistry
Polysaccharides - chemistry
Polysaccharides - metabolism
Receptors, Cell Surface - chemistry
Receptors, Cell Surface - metabolism
Reproduction
Signal Transduction
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Summary:Glycans are key participants in biological processes ranging from reproduction to cellular communication to infection. Revealing glycan roles and the underlying molecular mechanisms by which glycans manifest their function requires access to glycan derivatives that vary systematically. To this end, glycopolymers (polymers bearing pendant carbohydrates) have emerged as valuable glycan analogs. Because glycopolymers can readily be synthesized, their overall shape can be varied, and they can be altered systematically to dissect the structural features that underpin their activities. This review provides examples in which glycopolymers have been used to effect carbohydrate-mediated signal transduction. Our objective is to illustrate how these powerful tools can reveal the molecular mechanisms that underlie carbohydrate-mediated signal transduction.
ISSN:0306-0012
1460-4744
DOI:10.1039/c3cs60097a