Effects of aqueous leaf extract of Asystasia gangetica on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats

Asystasia gangentica (A. gangetica) belongs to the family Acanthaceae. It is used to treat hypertension, rheumatism, asthma, diabetes mellitus, and as an anthelmintic in South Africa, India, Cameroun, Nigeria, and Kenya respectively. It has also been reported to inhibit the angiotensin I converting...

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Bibliographic Details
Published in:BMC complementary and alternative medicine 2013-10, Vol.13 (1), p.283-283, Article 283
Main Authors: Mugabo, Pierre, Raji, Ismaila A
Format: Article
Language:English
Subjects:
Acanthaceae - chemistry
acetates
Angiotensin converting enzyme
Animals
anthelmintics
Antihypertensive Agents - administration & dosage
asthma
Asystasia gangetica
blood pressure
Blood Pressure - drug effects
Cardiovascular agents
Care and treatment
Chemical properties
Colleges & universities
complement
computers
diabetes mellitus
dose response
Drugs
Enzymes
Experiments
family
Health aspects
Heart rate
Heart Rate - drug effects
Humans
Hypertension
Hypertension - drug therapy
Hypertension - physiopathology
India
intravenous injection
Kenya
leaf extracts
Male
males
Medical research
Medicinal plants
Nigeria
Patient outcomes
Pharmacology
Pharmacy
Physiology
Plant Extracts - administration & dosage
Plant Leaves - chemistry
Rats
Rats, Inbred SHR
Rats, Wistar
rheumatoid arthritis
Rodents
Sodium
South Africa
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Summary:Asystasia gangentica (A. gangetica) belongs to the family Acanthaceae. It is used to treat hypertension, rheumatism, asthma, diabetes mellitus, and as an anthelmintic in South Africa, India, Cameroun, Nigeria, and Kenya respectively. It has also been reported to inhibit the angiotensin I converting enzyme (ACE) in-vitro. Therefore, the aim of this study is to investigate the in-vivo effect of aqueous leaf extract (ALE) of A. gangetica on the blood pressure (BP) and heart rate (HR) in anaesthetized male spontaneously hypertensive rats (SHR); and to elucidate possible mechanism(s) by which it acts. The ALE of A. gangetica (10-400 mg/kg), angiotensin I human acetate salt hydrate (ANG I, 3.1-100 μg/kg) and angiotensin II human (ANG II, 3.1-50 μg/kg) were administered intravenously. The BP and HR were measured via a pressure transducer connecting the femoral artery to a Powerlab and a computer for recording. A. gangetica significantly (p
ISSN:1472-6882
1472-6882
DOI:10.1186/1472-6882-13-283