Redox signaling in pathophysiology of hypertension

Reactive oxygen species (ROS) are products of normal cellular metabolism and derive from various sources in different cellular compartments. Oxidative stress resultant from imbalance between ROS generation and antioxidant defense mechanisms is important in pathogenesis of cardiovascular diseases, su...

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Bibliographic Details
Published in:Journal of biomedical science 2013-09, Vol.20 (1), p.69-69, Article 69
Main Authors: Majzunova, Miroslava, Dovinova, Ima, Barancik, Miroslav, Chan, Julie Y H
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Atherosclerosis
Cardiovascular System - metabolism
Cardiovascular System - physiopathology
Genes
Genetic transcription
Heart
Heart enlargement
Humans
Hypertension
Hypertension - etiology
Hypertension - physiopathology
Mice
Oxidation-Reduction
Physiological aspects
Proteins
Rats
Reactive Oxygen Species - metabolism
Review
Signal Transduction
Superoxide
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Summary:Reactive oxygen species (ROS) are products of normal cellular metabolism and derive from various sources in different cellular compartments. Oxidative stress resultant from imbalance between ROS generation and antioxidant defense mechanisms is important in pathogenesis of cardiovascular diseases, such as hypertension, heart failure, atherosclerosis, diabetes, and cardiac hypertrophy. In this review we focus on hypertension and address sources of cellular ROS generation, mechanisms involved in regulation of radical homeostasis, superoxide dismutase isoforms in pathophysiology of hypertension; as well as radical intracellular signaling and phosphorylation processes in proteins of the affected cardiovascular tissues. Finally, we discuss the transcriptional factors involved in redox-sensitive gene transcription and antioxidant response, as well as their roles in hypertension.
ISSN:1423-0127
1021-7770
1423-0127
DOI:10.1186/1423-0127-20-69