Bioavailability of phytochemicals and its enhancement by drug delivery systems

Highlights ► Drug delivery systems can overcome poor bioavailability of chemopreventives. ► Chemopreventives should be tagged to the target organ where they bioaccumulate. ► Chemopreventives should preferably be non-nutrient phytochemical to avoid imbalance in micronutrient metabolism. ► Chemopreven...

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Bibliographic Details
Published in:Cancer letters 2013-06, Vol.334 (1), p.133-141
Main Authors: Aqil, Farrukh, Munagala, Radha, Jeyabalan, Jeyaprakash, Vadhanam, Manicka V
Format: Article
Language:English
Subjects:
Anticarcinogenic Agents - administration & dosage
Anticarcinogenic Agents - pharmacokinetics
Antioxidants
Bioaccumulation
Bioavailability
Biological Availability
Biomarkers
Cancer therapies
Chemoprevention
Clinical trials
cyclodextrins
Cyclodextrins - administration & dosage
Cyclodextrins - pharmacokinetics
Dietary supplements
Disease prevention
Drug delivery
drug delivery systems
Drug Delivery Systems - methods
Drug dosages
drugs
Hematology, Oncology and Palliative Medicine
Humans
Liposomes
Lung cancer
Metabolism
Metabolites
Micelles
Nanochemoprevention
Nanoparticles
pharmacokinetics
phytochemicals
Phytochemicals - administration & dosage
Phytochemicals - pharmacokinetics
Polymeric implant
Polyphenols
Prostate cancer
Rodents
Selenium
Studies
Vitamin C
Vitamin E
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Summary:Highlights ► Drug delivery systems can overcome poor bioavailability of chemopreventives. ► Chemopreventives should be tagged to the target organ where they bioaccumulate. ► Chemopreventives should preferably be non-nutrient phytochemical to avoid imbalance in micronutrient metabolism. ► Chemopreventives as adjuvant treatment to traditional chemotherapies will establish their true potential in clinical settings.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2013.02.032