Theoretical models for coronary vascular biomechanics: Progress & challenges

A key aim of the cardiac Physiome Project is to develop theoretical models to simulate the functional behaviour of the heart under physiological and pathophysiological conditions. Heart function is critically dependent on the delivery of an adequate blood supply to the myocardium via the coronary va...

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Bibliographic Details
Published in:Progress in biophysics and molecular biology 2011-01, Vol.104 (1), p.49-76
Main Authors: Waters, Sarah L., Alastruey, Jordi, Beard, Daniel A., Bovendeerd, Peter H.M., Davies, Peter F., Jayaraman, Girija, Jensen, Oliver E., Lee, Jack, Parker, Kim H., Popel, Aleksander S., Secomb, Timothy W., Siebes, Maria, Sherwin, Spencer J., Shipley, Rebecca J., Smith, Nicolas P., van de Vosse, Frans N.
Format: Article
Language:English
Subjects:
Adaptation
Biomechanical Phenomena
Cellular mechanics
Coronary Circulation - physiology
Coronary Vessels - physiology
Haemodynamics
Heart - physiology
Humans
Integration
Mass transport
Mathematical and computational model
Mechanics
Models, Cardiovascular
Multi-scale
Myocardium - cytology
Myocardium - metabolism
Regulation
Vascular structure
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Summary:A key aim of the cardiac Physiome Project is to develop theoretical models to simulate the functional behaviour of the heart under physiological and pathophysiological conditions. Heart function is critically dependent on the delivery of an adequate blood supply to the myocardium via the coronary vasculature. Key to this critical function of the coronary vasculature is system dynamics that emerge via the interactions of the numerous constituent components at a range of spatial and temporal scales. Here, we focus on several components for which theoretical approaches can be applied, including vascular structure and mechanics, blood flow and mass transport, flow regulation, angiogenesis and vascular remodelling, and vascular cellular mechanics. For each component, we summarise the current state of the art in model development, and discuss areas requiring further research. We highlight the major challenges associated with integrating the component models to develop a computational tool that can ultimately be used to simulate the responses of the coronary vascular system to changing demands and to diseases and therapies.
ISSN:0079-6107
1873-1732
DOI:10.1016/j.pbiomolbio.2010.10.001