N-glycosylation profiling of plasma provides evidence for accelerated physiological aging in post-traumatic stress disorder

The prevalence of age-related diseases is increased in individuals with post-traumatic stress disorder (PTSD). However, the underlying biological mechanisms are still unclear. N -glycosylation is an age-dependent process, identified as a biomarker for physiological aging (GlycoAge Test). To investig...

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Bibliographic Details
Published in:Translational psychiatry 2013-10, Vol.3 (10), p.e320-e320
Main Authors: Moreno-Villanueva, M, Morath, J, Vanhooren, V, Elbert, T, Kolassa, S, Libert, C, Bürkle, A, Kolassa, I-T
Format: Article
Language:English
Subjects:
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692/53
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Adult
Aging, Premature - blood
Aging, Premature - metabolism
Behavioral Sciences
Biological Psychology
Case-Control Studies
Female
Glycosylation
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Neurosciences
Original
original-article
Pharmacotherapy
Polysaccharides - blood
Polysaccharides - metabolism
Psychiatry
Stress Disorders, Post-Traumatic - blood
Stress Disorders, Post-Traumatic - metabolism
Stress, Psychological - blood
Stress, Psychological - metabolism
Young Adult
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Summary:The prevalence of age-related diseases is increased in individuals with post-traumatic stress disorder (PTSD). However, the underlying biological mechanisms are still unclear. N -glycosylation is an age-dependent process, identified as a biomarker for physiological aging (GlycoAge Test). To investigate whether traumatic stress accelerates the aging process, we analyzed the N -glycosylation profile in n =13 individuals with PTSD, n =9 trauma-exposed individuals and in n =10 low-stress control subjects. Individuals with PTSD and trauma-exposed individuals presented an upward shift in the GlycoAge Test, equivalent to an advancement of the aging process by 15 additional years. Trauma-exposed individuals presented an intermediate N -glycosylation profile positioned between severely traumatized individuals with PTSD and low-stress control subjects. In conclusion, our data suggest that cumulative exposure to traumatic stressors accelerates the process of physiological aging.
ISSN:2158-3188
2158-3188
DOI:10.1038/tp.2013.93