A predictor of atheroma progression in patients achieving very low levels of low-density lipoprotein cholesterol

An aggressive reduction in low-density lipoprotein cholesterol (LDL-C) with statins produces regression or stabilization of coronary artery plaques. However, after achieving very low levels of LDL-C, atheroma regression is not observed in all patients. The purpose of the present study was to evaluat...

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Published in:American journal of cardiovascular disease 2013-01, Vol.3 (4), p.255-263
Main Authors: Nozue, Tsuyoshi, Yamamoto, Shingo, Tohyama, Shinichi, Fukui, Kazuki, Umezawa, Shigeo, Onishi, Yuko, Kunishima, Tomoyuki, Hibi, Kiyoshi, Terashima, Mitsuyasu, Michishita, Ichiro
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Language:English
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Summary:An aggressive reduction in low-density lipoprotein cholesterol (LDL-C) with statins produces regression or stabilization of coronary artery plaques. However, after achieving very low levels of LDL-C, atheroma regression is not observed in all patients. The purpose of the present study was to evaluate the determinants of atheroma progression despite achieving very low levels of LDL-C. The effects of 8-month statin therapy on coronary atherosclerosis were evaluated using virtual histology intravascular ultrasound in the TRUTH study. Of these, 33 patients who achieved an on-treatment LDL-C level of
ISSN:2160-200X
2160-200X