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Disseminated Histoplasmosis in a 13-year-old girl: a case report
Background: Disseminated histoplasmosis is a rare fungal infection and most documented cases are in immunecompromised individuals such as those with acquired immuno-deficiency syndrome. Objective: To describe a case of disseminated histoplasmosis in an adolescent girl. Method: We report a case of di...
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| Published in: | African health sciences 2013-01, Vol.13 (2), p.518-521 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 521 |
| container_issue | 2 |
| container_start_page | 518 |
| container_title | African health sciences |
| container_volume | 13 |
| creator | Ubesie, A C Okafo, O C Ibeziako, N S Onukwuli, V O Mbanefo, N R Uzoigwe, J C Bede, C Ibe, B C |
| description | Background: Disseminated histoplasmosis is a rare fungal infection and
most documented cases are in immunecompromised individuals such as
those with acquired immuno-deficiency syndrome. Objective: To describe
a case of disseminated histoplasmosis in an adolescent girl. Method: We
report a case of disseminated histoplasmosis in a 13-year-old
adolescent girl. She was admitted for 16 days because of neck masses of
3 years duration, generalized body swelling of 3 months and reduction
in urinary output of 2 months. She tested negative for human
immunodeficiency virus antibodies. Result: An autopsy was performed
because a definitive diagnosis could not be made while the patient was
still alive. The autopsy revealed central caseating areas in the lymph
nodes and membranoproliferative glomerulonephritis. The periodic
acid-Schiff staining technique for tissues showed viable yeast cells
suggestive of histoplasmosis. Zeihl-Neelsen's staining for
mycobacteria tuberculosis was negative. Conclusion: Undiagnosed case of
disseminated histoplasmosis while the patient was alive is being
reported in a 13-yearold girl. Disseminated histoplasmosis should be
considered as a differential diagnosis of childhood chronic infections
and malignancies as in Nigeria. |
| doi_str_mv | 10.4314/ahs.v13i2.45 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3824472</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1459151970</sourcerecordid><originalsourceid>FETCH-LOGICAL-b475t-dd9f813e0a244e62e755c8534d650dee5c825553dfc2077092ae9897c48532083</originalsourceid><addsrcrecordid>eNqVkT1PHDEQhi1EBITQUUcrkSJF9vDXrNcUURD5AAkpTVJbvvUcZ7S7vnj2iPj3ODk4BbpUtsePnrHnZexY8JlWQp_6Jc3uhIpypmGHHQgjbc2Bq92yb1peN5bDPntNdMu5bIQVe2xfaqnAQnvAPn2ORDjE0U8YqstIU1r1noZEkao4Vr4Sqr5Hn-vUh-om5v6s1DpPWGVcpTy9Ya8Wvic8elwP2c-vX35cXNbX379dXZxf13NtYKpDsItWKOReao2NRAPQtaB0aIAHxHKQAKDCopPcGG6lR9ta0-kCSd6qQ_Zx412t5wOGDscp-96tchx8vnfJR_f8ZoxLd5PunGpLRyOL4N2jIKdfa6TJ_Y4ZF4iBnIS2MVZzLQr2_gU2ROqw7_2Iaf1fqNBgBQhreEFPXqC3aZ3HMrDnwg8bqsuJqDxu-z3B3Z-wXQnb_Q3baSj4239HsoWf0i3AbAPMY-rjiFuiy9G7p2JRLkkobpR6AKWBs8s</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2586794041</pqid></control><display><type>article</type><title>Disseminated Histoplasmosis in a 13-year-old girl: a case report</title><source>PubMed Central</source><creator>Ubesie, A C ; Okafo, O C ; Ibeziako, N S ; Onukwuli, V O ; Mbanefo, N R ; Uzoigwe, J C ; Bede, C ; Ibe, B C</creator><creatorcontrib>Ubesie, A C ; Okafo, O C ; Ibeziako, N S ; Onukwuli, V O ; Mbanefo, N R ; Uzoigwe, J C ; Bede, C ; Ibe, B C</creatorcontrib><description>Background: Disseminated histoplasmosis is a rare fungal infection and
most documented cases are in immunecompromised individuals such as
those with acquired immuno-deficiency syndrome. Objective: To describe
a case of disseminated histoplasmosis in an adolescent girl. Method: We
report a case of disseminated histoplasmosis in a 13-year-old
adolescent girl. She was admitted for 16 days because of neck masses of
3 years duration, generalized body swelling of 3 months and reduction
in urinary output of 2 months. She tested negative for human
immunodeficiency virus antibodies. Result: An autopsy was performed
because a definitive diagnosis could not be made while the patient was
still alive. The autopsy revealed central caseating areas in the lymph
nodes and membranoproliferative glomerulonephritis. The periodic
acid-Schiff staining technique for tissues showed viable yeast cells
suggestive of histoplasmosis. Zeihl-Neelsen's staining for
mycobacteria tuberculosis was negative. Conclusion: Undiagnosed case of
disseminated histoplasmosis while the patient was alive is being
reported in a 13-yearold girl. Disseminated histoplasmosis should be
considered as a differential diagnosis of childhood chronic infections
and malignancies as in Nigeria.</description><identifier>ISSN: 1680-6905</identifier><identifier>EISSN: 1729-0503</identifier><identifier>EISSN: 1680-6905</identifier><identifier>DOI: 10.4314/ahs.v13i2.45</identifier><identifier>PMID: 24235958</identifier><language>eng</language><publisher>Uganda: Makerere University Medical School</publisher><subject>Adolescent ; Adolescents ; Autopsy ; Case studies ; Diagnosis, Differential ; Diagnostics ; Disseminated histoplasmosis ; Fatal Outcome ; Female ; Girls ; Health and Medicine ; Histoplasmosis - diagnosis ; Humans ; immune-competent, adolescent girl, Enugu ; Medical disorders ; Nigeria ; Original</subject><ispartof>African health sciences, 2013-01, Vol.13 (2), p.518-521</ispartof><rights>Copyright 2013 - African Health Sciences</rights><rights>Copyright © Makerere Medical School, Uganda 2013 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b475t-dd9f813e0a244e62e755c8534d650dee5c825553dfc2077092ae9897c48532083</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824472/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824472/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24235958$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ubesie, A C</creatorcontrib><creatorcontrib>Okafo, O C</creatorcontrib><creatorcontrib>Ibeziako, N S</creatorcontrib><creatorcontrib>Onukwuli, V O</creatorcontrib><creatorcontrib>Mbanefo, N R</creatorcontrib><creatorcontrib>Uzoigwe, J C</creatorcontrib><creatorcontrib>Bede, C</creatorcontrib><creatorcontrib>Ibe, B C</creatorcontrib><title>Disseminated Histoplasmosis in a 13-year-old girl: a case report</title><title>African health sciences</title><addtitle>Afr Health Sci</addtitle><description>Background: Disseminated histoplasmosis is a rare fungal infection and
most documented cases are in immunecompromised individuals such as
those with acquired immuno-deficiency syndrome. Objective: To describe
a case of disseminated histoplasmosis in an adolescent girl. Method: We
report a case of disseminated histoplasmosis in a 13-year-old
adolescent girl. She was admitted for 16 days because of neck masses of
3 years duration, generalized body swelling of 3 months and reduction
in urinary output of 2 months. She tested negative for human
immunodeficiency virus antibodies. Result: An autopsy was performed
because a definitive diagnosis could not be made while the patient was
still alive. The autopsy revealed central caseating areas in the lymph
nodes and membranoproliferative glomerulonephritis. The periodic
acid-Schiff staining technique for tissues showed viable yeast cells
suggestive of histoplasmosis. Zeihl-Neelsen's staining for
mycobacteria tuberculosis was negative. Conclusion: Undiagnosed case of
disseminated histoplasmosis while the patient was alive is being
reported in a 13-yearold girl. Disseminated histoplasmosis should be
considered as a differential diagnosis of childhood chronic infections
and malignancies as in Nigeria.</description><subject>Adolescent</subject><subject>Adolescents</subject><subject>Autopsy</subject><subject>Case studies</subject><subject>Diagnosis, Differential</subject><subject>Diagnostics</subject><subject>Disseminated histoplasmosis</subject><subject>Fatal Outcome</subject><subject>Female</subject><subject>Girls</subject><subject>Health and Medicine</subject><subject>Histoplasmosis - diagnosis</subject><subject>Humans</subject><subject>immune-competent, adolescent girl, Enugu</subject><subject>Medical disorders</subject><subject>Nigeria</subject><subject>Original</subject><issn>1680-6905</issn><issn>1729-0503</issn><issn>1680-6905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqVkT1PHDEQhi1EBITQUUcrkSJF9vDXrNcUURD5AAkpTVJbvvUcZ7S7vnj2iPj3ODk4BbpUtsePnrHnZexY8JlWQp_6Jc3uhIpypmGHHQgjbc2Bq92yb1peN5bDPntNdMu5bIQVe2xfaqnAQnvAPn2ORDjE0U8YqstIU1r1noZEkao4Vr4Sqr5Hn-vUh-om5v6s1DpPWGVcpTy9Ya8Wvic8elwP2c-vX35cXNbX379dXZxf13NtYKpDsItWKOReao2NRAPQtaB0aIAHxHKQAKDCopPcGG6lR9ta0-kCSd6qQ_Zx412t5wOGDscp-96tchx8vnfJR_f8ZoxLd5PunGpLRyOL4N2jIKdfa6TJ_Y4ZF4iBnIS2MVZzLQr2_gU2ROqw7_2Iaf1fqNBgBQhreEFPXqC3aZ3HMrDnwg8bqsuJqDxu-z3B3Z-wXQnb_Q3baSj4239HsoWf0i3AbAPMY-rjiFuiy9G7p2JRLkkobpR6AKWBs8s</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Ubesie, A C</creator><creator>Okafo, O C</creator><creator>Ibeziako, N S</creator><creator>Onukwuli, V O</creator><creator>Mbanefo, N R</creator><creator>Uzoigwe, J C</creator><creator>Bede, C</creator><creator>Ibe, B C</creator><general>Makerere University Medical School</general><general>Makerere Medical School</general><scope>RBI</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130101</creationdate><title>Disseminated Histoplasmosis in a 13-year-old girl: a case report</title><author>Ubesie, A C ; Okafo, O C ; Ibeziako, N S ; Onukwuli, V O ; Mbanefo, N R ; Uzoigwe, J C ; Bede, C ; Ibe, B C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b475t-dd9f813e0a244e62e755c8534d650dee5c825553dfc2077092ae9897c48532083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adolescents</topic><topic>Autopsy</topic><topic>Case studies</topic><topic>Diagnosis, Differential</topic><topic>Diagnostics</topic><topic>Disseminated histoplasmosis</topic><topic>Fatal Outcome</topic><topic>Female</topic><topic>Girls</topic><topic>Health and Medicine</topic><topic>Histoplasmosis - diagnosis</topic><topic>Humans</topic><topic>immune-competent, adolescent girl, Enugu</topic><topic>Medical disorders</topic><topic>Nigeria</topic><topic>Original</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ubesie, A C</creatorcontrib><creatorcontrib>Okafo, O C</creatorcontrib><creatorcontrib>Ibeziako, N S</creatorcontrib><creatorcontrib>Onukwuli, V O</creatorcontrib><creatorcontrib>Mbanefo, N R</creatorcontrib><creatorcontrib>Uzoigwe, J C</creatorcontrib><creatorcontrib>Bede, C</creatorcontrib><creatorcontrib>Ibe, B C</creatorcontrib><collection>Bioline International</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>African health sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ubesie, A C</au><au>Okafo, O C</au><au>Ibeziako, N S</au><au>Onukwuli, V O</au><au>Mbanefo, N R</au><au>Uzoigwe, J C</au><au>Bede, C</au><au>Ibe, B C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disseminated Histoplasmosis in a 13-year-old girl: a case report</atitle><jtitle>African health sciences</jtitle><addtitle>Afr Health Sci</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>13</volume><issue>2</issue><spage>518</spage><epage>521</epage><pages>518-521</pages><issn>1680-6905</issn><eissn>1729-0503</eissn><eissn>1680-6905</eissn><abstract>Background: Disseminated histoplasmosis is a rare fungal infection and
most documented cases are in immunecompromised individuals such as
those with acquired immuno-deficiency syndrome. Objective: To describe
a case of disseminated histoplasmosis in an adolescent girl. Method: We
report a case of disseminated histoplasmosis in a 13-year-old
adolescent girl. She was admitted for 16 days because of neck masses of
3 years duration, generalized body swelling of 3 months and reduction
in urinary output of 2 months. She tested negative for human
immunodeficiency virus antibodies. Result: An autopsy was performed
because a definitive diagnosis could not be made while the patient was
still alive. The autopsy revealed central caseating areas in the lymph
nodes and membranoproliferative glomerulonephritis. The periodic
acid-Schiff staining technique for tissues showed viable yeast cells
suggestive of histoplasmosis. Zeihl-Neelsen's staining for
mycobacteria tuberculosis was negative. Conclusion: Undiagnosed case of
disseminated histoplasmosis while the patient was alive is being
reported in a 13-yearold girl. Disseminated histoplasmosis should be
considered as a differential diagnosis of childhood chronic infections
and malignancies as in Nigeria.</abstract><cop>Uganda</cop><pub>Makerere University Medical School</pub><pmid>24235958</pmid><doi>10.4314/ahs.v13i2.45</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1680-6905 |
| ispartof | African health sciences, 2013-01, Vol.13 (2), p.518-521 |
| issn | 1680-6905 1729-0503 1680-6905 |
| language | eng |
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| source | PubMed Central |
| subjects | Adolescent Adolescents Autopsy Case studies Diagnosis, Differential Diagnostics Disseminated histoplasmosis Fatal Outcome Female Girls Health and Medicine Histoplasmosis - diagnosis Humans immune-competent, adolescent girl, Enugu Medical disorders Nigeria Original |
| title | Disseminated Histoplasmosis in a 13-year-old girl: a case report |
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