Primary Monophasic Synovial Sarcoma of the Tonsil: Immunohistochemical and Molecular Study of a Case and Review of the Literature

Synovial sarcoma (SS) arises primarily in the lower extremities with a predilection for sites in proximity to large joints, such as the knee. It rarely occurs in the head and neck region, and the tonsil is an unusual site for the tumor, with only eight previously published cases in this anatomical s...

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Bibliographic Details
Published in:Head & neck pathology (Totowa, N.J.) N.J.), 2013-12, Vol.7 (4), p.400-403
Main Authors: Soria-Céspedes, Danny, Galván-Linares, Aldo Iván, Oros-Ovalle, Cuauhtemoc, Gaitan-Gaona, Francisco, Ortiz-Hidalgo, Carlos
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - analysis
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Case Report
Dentistry
Humans
Immunohistochemistry
Male
Medicine
Medicine & Public Health
Middle Aged
Oncogene Proteins, Fusion - genetics
Oral and Maxillofacial Surgery
Otorhinolaryngology
Pathology
Reverse Transcriptase Polymerase Chain Reaction
Sarcoma, Synovial - genetics
Sarcoma, Synovial - metabolism
Sarcoma, Synovial - pathology
Tonsillar Neoplasms - genetics
Tonsillar Neoplasms - metabolism
Tonsillar Neoplasms - pathology
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Summary:Synovial sarcoma (SS) arises primarily in the lower extremities with a predilection for sites in proximity to large joints, such as the knee. It rarely occurs in the head and neck region, and the tonsil is an unusual site for the tumor, with only eight previously published cases in this anatomical site. We present a case of a primary monophasic SS arising in the right tonsil in a 63-year-old male. His medical history was noncontributory. Immunohistochemistry showed that cytokeratin OSCAR, EMA, Bcl-2, vimentin, PGP 9.5, and TLE1 were diffusely positive. A molecular analysis using RT-PCR indicated that the patient was positive for the SYT/SSX1 fusion transcript. A diagnosis of monophasic synovial sarcoma of the tonsil was made.
ISSN:1936-055X
1936-0568
DOI:10.1007/s12105-013-0440-5