Dissection of Calcium Signaling Events in Exocrine Secretion

The secretion of fluid and electrolytes by salivary gland acinar cells requires the coordinated regulation of multiple ion channel and transporter proteins, signaling components, and water transport. Importantly, neurotransmitter stimulated increase in the cytosolic free [Ca 2+ ] ([Ca 2+ ] i ) is cr...

Full description

Saved in:
Bibliographic Details
Published in:Neurochemical research 2011-07, Vol.36 (7), p.1212-1221
Main Author: Ambudkar, Indu S.
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Calcium - metabolism
Calcium Channels - physiology
Calcium Signaling - physiology
Cell Biology
Cytosol - metabolism
Endoplasmic Reticulum - metabolism
Inositol 1,4,5-Trisphosphate - physiology
Inositol 1,4,5-Trisphosphate Receptors - physiology
Mice
Microfilament Proteins - physiology
Nerve Tissue Proteins - physiology
Neurochemistry
Neurology
Neurosciences
Original Paper
Receptors, Muscarinic - physiology
Salivary Glands - secretion
Salivation - physiology
Signal Transduction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The secretion of fluid and electrolytes by salivary gland acinar cells requires the coordinated regulation of multiple ion channel and transporter proteins, signaling components, and water transport. Importantly, neurotransmitter stimulated increase in the cytosolic free [Ca 2+ ] ([Ca 2+ ] i ) is critical for the regulation of salivary gland secretion as it regulates several major ion fluxes that together establish the sustained osmotic gradient to drive fluid secretion. The mechanisms that act to modulate these increases in [Ca 2+ ] i are therefore central to the process of salivary fluid secretion. Such modulation involves membrane receptors for neurotransmitters, as well as mechanisms that mediate intracellular Ca 2+ release, and Ca 2+ entry, as well as those that maintain cellular Ca 2+ homeostasis. Together, these mechanisms determine the spatial and temporal aspects of the [Ca 2+ ] i signals that regulate fluid secretion. Molecular cloning of these transporters and channels as well as development of mice lacking these proteins has established the physiological significance of key components that are involved in regulating [Ca 2+ ] i in salivary glands. This review will discuss these important studies and the findings which have led to resolution of the Ca 2+ signaling mechanisms that determine salivary gland fluid secretion.
ISSN:0364-3190
1573-6903
DOI:10.1007/s11064-011-0465-7