Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond

Thrombin is the protease involved in blood coagulation. Its deregulation can lead to hemostatic abnormalities, which range from subtle subclinical to serious life-threatening coagulopathies, i.e., during septicemia. Additionally, thrombin plays important roles in many (patho)physiological conditions...

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Bibliographic Details
Published in:Journal of molecular medicine (Berlin, Germany) Germany), 2013-11, Vol.91 (11), p.1257-1271
Main Authors: Danckwardt, Sven, Hentze, Matthias W., Kulozik, Andreas E.
Format: Article
Language:English
Subjects:
Adaptive Immunity
Animals
Biomedical and Life Sciences
Biomedicine
Gene Expression Regulation
Hemostasis
Human Genetics
Humans
Immunity, Innate
Inflammation - genetics
Inflammation - immunology
Inflammation - metabolism
Internal Medicine
Molecular Medicine
Molecular Targeted Therapy - methods
Neoplasms - genetics
Neoplasms - immunology
Neoplasms - metabolism
Review
Thrombin - genetics
Thrombin - immunology
Thrombin - metabolism
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Summary:Thrombin is the protease involved in blood coagulation. Its deregulation can lead to hemostatic abnormalities, which range from subtle subclinical to serious life-threatening coagulopathies, i.e., during septicemia. Additionally, thrombin plays important roles in many (patho)physiological conditions that reach far beyond its well-established role in stemming blood loss and thrombosis, including embryonic development and angiogenesis but also extending to inflammatory processes, complement activation, and even tumor biology. In this review, we will address thrombin’s broad roles in diverse (patho)physiological processes in an integrative way. We will also discuss thrombin as an emerging major target for novel therapies.
ISSN:0946-2716
1432-1440
DOI:10.1007/s00109-013-1074-5